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MetabolomicsCE-MS Metabolomic and LC-MS Proteomic Analyses of Breast Cancer Exosomes Reveal Alterations in Purine and Carnitine Metabolism

A nano sheath-flow capillary electrophoresis mass spectrometry (CE-MS) system with electrospray ionization was used to profile cationic metabolite cargo in exosomes secreted by non-tumorigenic MCF-10A and tumorigenic MDA-MB-231 breast epithelial cells. CE-MS-based metabolomics revealed increased ...

2024-11-14 | MTBLS11190 | MetaboLights
MetabolomicsBranched-chain ketoacids derived from cancer cells modulate macrophage polarization and metabolic reprogramming

Macrophages are prominent immune cells in the tumor microenvironment that can be educated into pro-tumoral phenotype by tumor cells to favor tumor growth and metastasis. The mechanisms that mediate a mutualistic relationship between tumor cells and macrophages remain poorly characterized. Here, w...

2022-10-03 | MTBLS4497 | MetaboLights
MetabolomicsTargeting the SREBP-dependent lipidomic reprogramming by virus infection for broad-spectrum therapeutic intervention
Viruses are obligate intracellular parasites that exploit the host metabolic machineries to meet their extraordinary biosynthetic demands. Integrative transcriptomic and lipidomic profiling confirmed that Middle East respiratory syndrome coronavirus (MERS-CoV) infection reprograms the host lipid met...
2018-11-26 | MTBLS762 | MetaboLights
TranscriptomicsAn Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming [AS microarray]
Alternative splicing (AS) is a key process underlying the expansion of proteomic diversity and the regulation of gene expression. However, the contribution of AS to the control of embryonic stem cell (ESC) pluripotency is not well understood. Here, we identify an evolutionarily conserved ESC-specifi...
ORGANISM(S): Homo sapiens 
2011-09-14 | E-GEOD-31948 | biostudies-arrayexpress
ProteomicsTMT analysis of early proteome events in direct cardiomyocyte reprogramming
Direct reprogramming of fibroblasts into cardiomyocyte-like cells (iCM) holds great potential for heart regeneration and disease modeling and may lead to future therapeutic applications in human patients with heart disease. Currently, the application of this technology is limited by our lack of unde...
ORGANISM(S): Mus musculus (Mouse) 
2018-02-19 | PXD006152 | Pride
Mef Gmt Orbitrap velos Hcd Fibroblast 
ProteomicsCanonical and isomiR products of miR-142 enhance dendritic cell reprogramming
MicroRNAs (miRNAs) regulate gene expression and generate isoforms (isomiRs) with distinct targeting properties, but their roles in cellular specification and reprogramming remain poorly understood. Here, we investigated miRNAs and isomiRs during direct reprogramming to conventional type 1 dendritic ...
ORGANISM(S): Homo sapiens (Human) 
2026-07-16 | PXD077362 | Pride
Reprogramming Mirna Data-independent acquisition Dendritic cells 
ProteomicsCanonical and isomiR products of miR-142 enhance dendritic cell reprogramming
MicroRNAs (miRNAs) regulate gene expression and generate isoforms (isomiRs) with distinct targeting properties, but their roles in cellular specification and reprogramming remain poorly understood. Here, we investigated miRNAs and isomiRs during direct reprogramming to conventional type 1 dendritic ...
ORGANISM(S): Homo sapiens (Human) 
2026-07-16 | PXD058915 | Pride
Reprogramming Mirna Data-independent acquisition Dendritic cells 
UnknownProteomic analysis of early reprogramming events in murine somatic cells incubated with Xenopus laevis oocyte extracts demonstrates network associations with induced pluripotency markers.
Not available
S-EPMC3726144 | biostudies-literature
ProteomicsProteomic Landscape of Porcine Induced Neural Stem Cell Reprogramming and Differentiation
Background: Direct reprogramming of somatic cells into induced neural stem cells (iNSCs) holds strong potential for regenerative medicine, especially in large animal models like pigs, which are crucial for translational and preclinical research. However, the molecular mechanisms driving porcine fibr...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2025-05-26 | PXD063568 | Pride
Pinscs  porcine  proteomics  direct reprogramming  neuronal differentiation  mass spectrometry Induced neural stem cells 
ProteomicsDiscovery of potential candidate proteins reprogramming spinal cord derived astrocytes into neurons by proteomic analysis
Spinal cord injury (SCI) is a common but devastating trauma of the central nerve system. In this study, we reprogrammed cultured spinal-cord reactive astrocytes into neurons by Neurod1 expression. The mechanism of programmed conversion from astrocytes to neurons has not been clarified yet. Thus, we ...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-09-08 | PXD016097 | Pride
Spinal cord injury Astrocytes Neurons Label-free proteomic analysis Reprogramming 
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