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MetabolomicsIntegrated proteomic and metabolomic profiling reveals molecular signatures underlying invasiveness in non-functioning pituitary adenomas

Pituitary adenomas constitute 10 to 25% of intracranial tumors, rendering them one of the most prevalent types of brain tumors. While the majority of pituitary adenomas are benign, ~35% exhibit invasive behavior. Compared with their non-invasive counterparts, invasive pituitary adenomas are more ...

2025-12-09 | MTBLS13478 | MetaboLights
MetabolomicsDIA-based LC-MS proteomic profiling of serum from asthma patients with different TCM syndromes
Serum samples were collected from healthy controls and asthma patients classified into lung qi deficiency and phlegm turbidity obstructing lung syndromes. DIA LC-MS was performed to acquire proteomic data, differential proteins and related molecular pathways were analyzed to explore serum molecular ...
2026-09-02 | MTBLS14938 | MetaboLights
MetabolomicsMulti-0mics and Machine Learning-Based Profiling of Severity signatures in Mycoplasma Pneumoniae Infection in children

Mycoplasma pneumoniae pneumonia (MPP) is a common respiratory infection in children. Yet the mechanisms driving its progression to severe disease remain poorly understood. This study employs a comprehensive proteomic and metabolomic approach to elucidate severity-related pathways and identify pot...

2026-01-04 | MTBLS13511 | MetaboLights
MetabolomicsValidation: Multi-Omics and Machine Learning-Based Profiling of Severity Signatures in Mycoplasma Pneumoniae Infection in Children

Mycoplasma pneumoniae pneumonia (MPP) is a common respiratory infection in children, yet the mechanisms driving its progression to severe disease remain poorly understood. This study employs a comprehensive proteomic and metabolomic approach to elucidate severity-related pathways and identify pot...

2026-01-05 | MTBLS13504 | MetaboLights
ProteomicsProteomic and Genomic Signatures of Repeat-instability in Cancer and Adjacent Normal Tissues
Repetitive sequences are hotspots of evolution at multiple levels. However, due to technical difficulties involved in their assembly and analysis, the role of repeats in tumor evolution is poorly understood. We developed a rigorous motif-based methodology to quantify variations in the repeat content...
ORGANISM(S): Homo sapiens (Human) 
2020-06-02 | PXD012574 | Pride
Tumor evolution Repeat-instability Proteomic signatures 
MetabolomicsLongitudinal Deep Multi-Omics Profiling in aCLN3Δex7/8Minipig Model Reveals Novel Biomarker Signatures for Batten Disease
Development of therapies for CLN3 Batten disease, a rare pediatric lysosomal storage disorder, has been hindered by the lack of etiological insights and translatable biomarkers to clinics. Here, we used a deep multi-omics approach to discover new biomarkers using longitudinal serum samples from a po...
2025-08-13 | MTBLS1107 | MetaboLights
GenomicsTranscriptomic and Proteomic Signatures Following AS03-adjuvanted Influenza A/H7N9 Vaccine
Transcriptomic and Proteomic Signatures Following AS03-adjuvanted Influenza A/H7N9 Vaccine
PRJNA1207538 | ENA
ProteomicsProteomic cellular signatures of kinase inhibitor-induced cardiotoxicity
Drug Toxicity Signature Generation Center (DToxS) at the Icahn School of Medicine at Mount Sinai is an integral part of the NIH Library of Integrated Network-Based Cellular Signatures (LINCS) program. A key aim of DToxS is to generate both proteomic and transcriptomic signatures that cab predict adv...
ORGANISM(S): Homo sapiens (Human) 
2021-10-18 | PXD014791 | Pride
Cardiotoxicity Drug Signature Proteomics Mass spectrometry Kinase inhibitor 
TranscriptomicsComprehensive proteomic and transcriptomic characterization of hepatic expression signatures affected in p14 liver conditional knockout mice
Scaffold proteins regulate intracellular MAP kinase signaling by providing critical spatial and temporal specificity. We have shown previously that the scaffold protein MEK1 partner (MP1) is localized to late endosomes by the adaptor protein p14. Using conditional gene disruption of p14 in livers of...
ORGANISM(S): Mus musculus 
2011-02-01 | E-GEOD-24461 | biostudies-arrayexpress
GenomicsIdentification of state-specific proteomic and transcriptomic signatures of microglia-derived extracellular vesicles [mirna-seq]
Identification of state-specific proteomic and transcriptomic signatures of microglia-derived extracellular vesicles [mirna-seq]
PRJNA1003105 | ENA
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