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MetabolomicsMulti-omics and biophysical phosphoproteomics uncover functional phosphorylation networks of BRAFV600E-driven signaling

Dysregulated kinase activity drives oncogenic signalling, perturbs cellular homeostasis, and promotes tumour progression. Despite major success in targeting kinases therapeutically, the downstream consequences of kinase inhibition and the mechanisms underlying drug resistance remain incompletely ...

2025-12-09 | MTBLS7390 | MetaboLights
ProteomicsFAS Inhibited Proteomics and Phosphoproteomics Profiling of Colorectal Cancer Spheroids shows Activation of Ferroptotic Death Mechanism
Colorectal cancer (CRC) is projected to become the third most diagnosed and third most fatal cancer in the United States by 2024, with early onset CRC on the rise. Research is constantly underway to discover novel therapeutics for the treatment of various cancers to improve patient outcomes and surv...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD050987 | Pride
Phosphoproteomics Mass spectrometry Colorectal cancer Cancer Proteomics Data-independent acquisition Spheroids 
GenomicsIntegration of transcriptomics, proteomics, phosphoproteomics analysis for characterization of pulmonary arterial hypertension in Chinese people
Integration of transcriptomics, proteomics, phosphoproteomics analysis for characterization of pulmonary arterial hypertension in Chinese people
PRJNA1138715 | ENA
UnknownIntegrative proteomics, phosphoproteomics and acetylation proteomics analyses of acute pancreatitis in rats
Not available
S-EPMC10266050 | biostudies-literature
UnknownExcessive Inorganic Phosphate Burden Perturbed Intracellular Signaling: Quantitative Proteomics and Phosphoproteomics Analyses.
Not available
S-EPMC8795896 | biostudies-literature
ProteomicsPhosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes
Acute myeloid leukemia (AML) is a disease with poor outcome but patients harbouring certain chromosomal rearrangements or complex karyotypes have particularly adverse prognosis. For these patients, targeted therapies have not yet made a significant clinical impact. To understand the molecular landsc...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD032980 | Pride
Aml Phosphoproteomics Genomics Kmt2a Impdh Drug screen Nucleolus Proteomics 
UnknownIntegrative proteomics and phosphoproteomics in pulmonary arterial hypertension.
Not available
S-EPMC6901481 | biostudies-literature
UnknownEffects of MEK inhibitors GSK1120212 and PD0325901 in vivo using 10-plex quantitative proteomics and phosphoproteomics.
Not available
S-EPMC4515953 | biostudies-literature
ProteomicsIntegrative proteomics and phosphoproteomics reveals phosphorylation networks involved in maintenance and expression of embryogenic competence in sugarcane callus
Sugarcane (Saccharum spp.) is one of the most important crops for sugar, biofuels and bioenergy production, becoming an important commodity in the world agricultural market for more than 100 countries. In this study, label-free quantitative proteomics and phosphoproteomics analyses were performed to...
ORGANISM(S): Saccharum hybrid cultivar SP80-3280 
2022-05-07 | PXD027388 | Pride
Label-free phosphoproteomics Embryo development Somatic embryogenesis Sugarcane 
UnknownProteomics and phosphoproteomics to study Tuina reverses capsule fibrosis in frozen shoulder: a research report based on rats.
Not available
S-EPMC10770356 | biostudies-literature
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