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ProteomicsPropensity for proto-gene emergence in bacteria
The birth of new genes from non-coding sequences has been postulated to be preceded by a proto-gene phase, in which a sequence is translated into protein but does not exhibit hallmarks of a clear function. Despite the abundance of such proto-genes in bacterial genomes, the frequency of their emergen...
ORGANISM(S): Escherichia coli Bacteria 
2025-09-19 | PXD062120 | Pride
Proto-genes Mass spectrometry Bacteria De novo gene evolution 
UnknownPromoter recruitment drives the emergence of proto-genes in a long-term evolution experiment with Escherichia coli.
Not available
S-EPMC11101190 | biostudies-literature
UnknownCharacterization of Leukemia-Inducing Genes Using a Proto-Oncogene/Homeobox Gene Retroviral Human cDNA Library in a Mouse In Vivo Model.
Not available
S-EPMC4659616 | biostudies-literature
TranscriptomicsVerification of the quality of the retroviral cDNA library composed of 176 proto-oncogenes and HOX genes
We constructed retroviral cDNA library of 176 proto-oncogenes and HOX genes to screen for the leukemia initiating gene combinations. The present submission is the NGS data of the PCR products of the whole inserts from the library itself and the bone marrow cells infected with retroviral library
ORGANISM(S): Homo sapiens 
2016-11-10 | GSE74806 | GEO
UnknownScreening of mutations in the additional sex combs like 1, transcriptional regulator, tumor protein p53, and KRAS proto-oncogene, GTPase/NRAS proto-oncogene, GTPase genes of patients with myelodysplastic syndrome.
Not available
S-EPMC5590036 | biostudies-literature
UnknownPhylogenetic analysis of the core histone doublet and DNA topo II genes of Marseilleviridae: evidence of proto-eukaryotic provenance.
Not available
S-EPMC5704553 | biostudies-literature
TranscriptomicsCombining laser microdissection and RNA-seq to chart the transcriptional landscape of fungal development
RNA-seq analysis of developmental stages from the filamenous ascomycete Sordaria macrospora. Using laser capture microdissection, we separated protoperithecia (young fruiting bodies) from the surrounding hyphae. RNA isolation and amplification from 150 protoperithecia yields enough material for RNA-...
ORGANISM(S): Sordaria macrospora 
2012-10-01 | E-GEOD-33668 | biostudies-arrayexpress
UnknownEffects of DNA methylation on expression of tumor suppressor genes and proto-oncogene in human colon cancer cell lines.
Not available
S-EPMC4656656 | biostudies-literature
GenomicsSelective transcriptional regulation by Myc in cellular growth control and lymphomagenesis [DNAse-Seq]
The c-myc proto-oncogene product, Myc, is a transcription factor that binds thousands of genomic loci. Recent work suggested that rather than up- and down-regulating selected groups of genes, Myc targets all active promoters and enhancers in the genome (a phenomenon termed "invasion") and ...
ORGANISM(S): Mus musculus 
2014-07-07 | E-GEOD-50823 | biostudies-arrayexpress
TranscriptomicsSelective transcriptional regulation by Myc in cellular growth control and lymphomagenesis [RNA-Seq]
The c-myc proto-oncogene product, Myc, is a transcription factor that binds thousands of genomic loci. Recent work suggested that rather than up- and down-regulating selected groups of genes, Myc targets all active promoters and enhancers in the genome (a phenomenon termed "invasion") and ...
ORGANISM(S): Mus musculus 
2014-07-07 | E-GEOD-51008 | biostudies-arrayexpress
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