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ProteomicsBroad-range metalloprotease profiling in plants uncovers immunity provided by defence-related metalloenzyme
Plants encode for >100 metalloproteases representing >19 different protein families. Tools to study this large and diverse class of proteases have not yet been introduced into plant science. Here, we used hydroxamate-based photoaffinity probes to explore plant proteomes for metalloproteases. We dete...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) Nicotiana benthamiana 
2022-08-12 | PXD032265 | Pride
Photoaffinity labelling Arabidopsis Prp27 Metalloproteases Immunity 
UnknownEstablishing quantitative real-time quaking-induced conversion (qRT-QuIC) for highly sensitive detection and quantification of PrPSc in prion-infected tissues.
Not available
S-EPMC3893511 | biostudies-literature
UnknownBroad-range metalloprotease profiling in plants uncovers immunity provided by defence-related metalloenzyme.
Not available
S-EPMC9322406 | biostudies-literature
UnknownLive imaging of prions reveals nascent PrPSc in cell-surface, raft-associated amyloid strings and webs.
Not available
S-EPMC3912534 | biostudies-literature
ProteomicsPrP concentration in the central nervous system: regional variability, genotypic effects, and pharmacodynamic impact
Prion protein (PrP) concentration controls the kinetics of prion replication and is a genetically and pharmacologically validated therapeutic target for prion disease. In order to evaluate PrP concentration as a pharmacodynamic biomarker and assess its contribution to known prion disease risk factor...
ORGANISM(S): Homo Sapiens Rattus Norvegicus 
2022-02-28 | PXD031432 | panorama
TranscriptomicsTranscriptome analysis of peripheral lymphoid tissue immediately before and after the detection of PrPSc in sheep scrapie
Sheep scrapie is a transmissible spongiform encephalopathy (TSE), which are invariably fatal neurodegenerative diseases of the central nervous system (CNS). Accumulation of the misfolded prion protein, PrPSc in the CNS results in progressive neurodegenerative disease. For many transmissible spongif...
ORGANISM(S): Ovis aries 
2014-02-20 | E-MTAB-2327 | biostudies-arrayexpress
TranscriptomicsInducible expression of PrPC in mouse skeletal muscles results in myopathy characterized by changes in gene expression
Over-expression of wild type PrP in skeletal muscles is sufficient to cause a primary myopathy with no signs of peripheral neuropathy, possibly due to accumulation of a cytotoxic truncated form of PrP and/or PrP aggregation. In this study we used DNA microarrays to identify 1499 transcripts that ar...
ORGANISM(S): Mus musculus 
2008-08-27 | E-GEOD-12576 | biostudies-arrayexpress
ProteomicsN-terminal acetylation for identification of cleavage sites on immunoprecipitated PrP
In-gel N-terminal acetylation of immunoprecipitated prion protein for identification of cleavage sites. Mouse expressing either WT or mutant (S3) form of PrP were used in this study. Three replicates from single brains were included in this experiment.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-07-27 | MSV000092543 | MassIVE
TranscriptomicsTranscriptome analysis of peripheral lymphoid tissue immediately before and after the detection of PrPSc in sheep scrapie 2
Sheep scrapie is a transmissible spongiform encephalopathy (TSE), which are invariably fatal neurodegenerative diseases of the central nervous system (CNS). Accumulation of the misfolded prion protein, PrPSc in the CNS results in progressive neurodegenerative disease. For many transmissible spongif...
ORGANISM(S): Ovis aries 
2014-04-06 | E-MTAB-2330 | biostudies-arrayexpress
ProteomicsSubtiligase N-terminomics for identification of cleavage sites in mice brain and immunoprecipitated PrP
Subtiligase-based N-terminomics (Abu N-terminal tagging) of whole mouse brain and immunoprecipitated prion protein. Mouse expressing either WT or mutant (S3) form of PrP were used in this study. Five replicates for single brain experiments and one replicate for combined brains approach are included....
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-07-27 | MSV000092542 | MassIVE
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