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ProteomicsAffinity purification of PRPS complex in human cultured cells (HEK293T)- LC-MS/MS
Phosphoribosyl pyrophosphate synthetase (PRPS) is an enzyme conserved across all forms of life, tracing back to the last universal common ancestor (LUCA). PRPS catalyzes the rate-limiting step in converting ribose-5-phosphate (R5P) to phosphoribosyl pyrophosphate (PRPP), a crucial precursor in the b...
ORGANISM(S): Homo sapiens (Human) 
2025-05-13 | PXD058828 | Pride
Prps complex Prps1 Prps2 Prpsap2 Lc-ms/ms 
ProteomicsAffinity purification of PRPS complex in mouse cultured cells (NIH3T3)- LC-MS/MS
Phosphoribosyl pyrophosphate synthetase (PRPS) is an enzyme conserved across all forms of life, tracing back to the last universal common ancestor (LUCA). PRPS catalyzes the rate-limiting step in converting ribose-5-phosphate (R5P) to phosphoribosyl pyrophosphate (PRPP), a crucial precursor in the b...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-13 | PXD058829 | Pride
Prps complex Prps1 Prps2 Prpsap2 Lc-ms/ms 
ProteomicsIdentification of high molecular weight protein/protein complexes in human cultured cells (HEK293T) LC-MS/MS
Phosphoribosyl pyrophosphate synthetase (PRPS) is a highly conserved enzyme that conducts the chokepoint reaction of nucleotide biosynthesis by converting ribose-5-phosphate (R-5-P) to phosphoribosyl pyrophosphate (PRPP). Due to the presence of multiple isoforms and related PRPS-associated proteins ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-13 | PXD059156 | Pride
Prps complex High molecular weight proteins Protein complexes Megadalton assemblies Lc-ms/ms 
UnknownEvolutionary origins and innovations sculpting the mammalian PRPS enzyme complex.
Not available
S-EPMC11476008 | biostudies-literature
UnknownThe role of gene duplication and paralog specialisation in the evolution of the mammalian PRPS complex.
Not available
S-EPMC12238573 | biostudies-literature
GenomicsPRPS activity governs redox homeostasis in MYC-driven lymphoma
PRPS activity governs redox homeostasis in MYC-driven lymphoma
PRJNA1188578 | ENA
TranscriptomicsPRPS activity governs redox homeostasis in MYC-driven lymphoma
Myc hyperactivation coordinately regulates numerous metabolic processes to drive lymphomagenesis. However, the temporal and epistatic relationships between the medley of pathways, factors, and mechanisms that must functionally cooperate to preserve homeostasis in Myc-overexpressing cells remain larg...
ORGANISM(S): Mus musculus 
2025-02-20 | GSE282435 | GEO
UnknownRemoving unwanted variation from large-scale RNA sequencing data with PRPS.
Not available
S-EPMC9849124 | biostudies-literature
TranscriptomicsRate Limiting Enzymes in Nucleotide Metabolism Synchronize Nucleotide Biosynthesis and Chromatin Formation [RNA-Seq]
Fundamental cellular processes including replication, transcription, and repair rely on both an adequate nucleotide supply and sufficient availability of new histones. Chromatin disassembly and reassembly is crucial to maintain genome stability, and is regulated by the orderly engagement of histones...
ORGANISM(S): Homo sapiens 
2025-09-16 | GSE307948 | GEO
GenomicsRate Limiting Enzymes in Nucleotide Metabolism Synchronize Nucleotide Biosynthesis and Chromatin Formation [ATAC-Seq]
Fundamental cellular processes including replication, transcription, and repair rely on both an adequate nucleotide supply and sufficient availability of new histones. Chromatin disassembly and reassembly is crucial to maintain genome stability, and is regulated by the orderly engagement of histones...
ORGANISM(S): Homo sapiens 
2025-09-16 | GSE307947 | GEO
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