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ProteomicsIdentification of human PRRC2B isoform interactors
Two isoforms (Long isoform ~220 KDa, short isoform ~150 KDa) of the human PRRC2B protein (Uniprot accession Q5JSZ5) were recombinantly expressed with an HA-tag in HEK293 cell lines. The goal of the experiment is to identify differential interactors of the short vs long isoforms, in addition to their...
ORGANISM(S): Homo sapiens (Human) 
2025-10-26 | PXD057527 | Pride
Mass spectrometry Ip-ms Prrc2b Lc-ms/ms 
ProteomicsIdentification of PRRC2B methylation sites
It was hypothesized that the human PRRC2B protein (Uniprot accession Q5JSZ5) interacts with its RNA binding targets via methylated arginines. The protein contains at least two RG rich motifs (residues 1061-1080, and 1104-1124), in which the arginines are hypothesized to be methylated. The goal of th...
ORGANISM(S): Homo sapiens (Human) 
2025-10-26 | PXD057790 | Pride
Methylation Prrc2b Ip Chymotrypsin Dap5 Lc-ms/ms 
GenomicsThe binding RNAs of Prrc2b in brain tissues of Prrc2b-HA knock-in mice [RIP-Seq]
The binding RNAs of Prrc2b in brain tissues of Prrc2b-HA knock-in mice [RIP-Seq]
PRJNA1017793 | ENA
OtherThe binding RNAs of Prrc2b in brain tissues of Prrc2b-HA knock-in mice [RIP-Seq]
We performed HA RIP-seq in cerebral cortexes of WT and Prrc2b-HA knockin mice at P4 to further analyze genes that Prrc2b selectively binds.
ORGANISM(S): Mus musculus 
2025-09-15 | GSE243309 | GEO
UnknownRNA binding protein PRRC2B mediates translation of specific mRNAs and regulates cell cycle progression.
Not available
S-EPMC10287950 | biostudies-literature
UnknownLoss-of-function of RNA-binding protein PRRC2B causes translational defects and congenital cardiovascular malformation.
Not available
S-EPMC11469349 | biostudies-literature
GenomicsRNA binding protein PRRC2B mediates translation of specific proteins and regulates cell cycle progression [PAR_Clip-seq]
RNA binding protein PRRC2B mediates translation of specific proteins and regulates cell cycle progression [PAR_Clip-seq]
PRJNA908728 | ENA
TranscriptomicsRNA binding protein PRRC2B mediates translation of specific proteins and regulates cell cycle progression [Polysome-seq]
Accumulating evidence suggests that posttranscriptional regulation of gene expression, including regulation of RNA splicing, transport, modification, translation, and degradation, primarily relies on RNA binding proteins (RBPs). However, the functions of many RBPs remain understudied. Here, we chara...
ORGANISM(S): Homo sapiens 
2023-04-20 | GSE220058 | GEO
OtherRNA binding protein PRRC2B mediates translation of specific proteins and regulates cell cycle progression [PAR_Clip-seq]
Accumulating evidence suggests that posttranscriptional regulation of gene expression, including regulation of RNA splicing, transport, modification, translation, and degradation, primarily relies on RNA binding proteins (RBPs). However, the functions of many RBPs remain understudied. Here, we chara...
ORGANISM(S): Homo sapiens 
2023-04-20 | GSE220057 | GEO
UnknownThe Role of PRRC2B in Cerebral Vascular Remodeling Under Acute Hypoxia in Mice.
Not available
S-EPMC10477837 | biostudies-literature
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