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GenomicsProteasome regulator PSME4 reduces cellular inflammation and promotes an immunosuppressive tumor microenvironment
Proteasome regulator PSME4 reduces cellular inflammation and promotes an immunosuppressive tumor microenvironment
PRJEB53036 | ENA
TranscriptomicsProteasome regulator PSME4 reduces cellular inflammation and promotes an immunosuppressive tumor microenvironment
We observed that proteasome regulator PSME4 inhibits antigen presentation and reduces cellular inflammation in lung adenocarcinoma. As tumor inflammation and antigenicity are key to anti-tumor immunity, we examined the effect of PSME4 in vivo by injecting mice with either KP1.9 or KP1.9PSME4_KD lun...
ORGANISM(S): Mus musculus 
2023-03-04 | E-MTAB-10745 | biostudies-arrayexpress
Genomics­The proteasome regulator PSME4 reduces the response to immunotherapy by abrogating tumor immunogenicity in NSCLC
­The proteasome regulator PSME4 reduces the response to immunotherapy by abrogating tumor immunogenicity in NSCLC
PRJNA831833 | ENA
Transcriptomics­The proteasome regulator PSME4 reduces the response to immunotherapy by abrogating tumor immunogenicity in NSCLC
Disruption in proteostasis is a hallmark of cancer, with aberrations in proteasome-mediated degradation highly implicated in this malignancy. Proteasomes further bear critical importance in tumor immunogenicity by regulating inflammatory signaling, promoting immune cell activation and playing a cruc...
ORGANISM(S): Homo sapiens 
2023-02-26 | GSE201460 | GEO
UnknownThe Proteasome Activator PA200/PSME4: An Emerging New Player in Health and Disease.
Not available
S-EPMC9406137 | biostudies-literature
UnknownThe role of proteasome activators PA28αβ and PA200 in brown adipocyte differentiation and function.
Not available
S-EPMC10187037 | biostudies-literature
ProteomicsLung Adenocarcinoma (A549) Immunopeptidomics
Alterations in cellular antigen processing and presenting machinery has gained increased interest as a hallmark of cancer-related inflammation. Growing evidence suggest that proteasome composition and immunoproteasome expression can influence antigen processing. By performing immunopeptidomics on A5...
ORGANISM(S): Homo sapiens (Human) 
2023-03-30 | PXD028364 | Pride
A549 Nsclc Immunopeptidome Hla 
ProteomicsLung Adenocarcinoma (A549) Immunopeptidomics
Alterations in cellular antigen processing and presenting machinery has gained increased interest as a hallmark of cancer-related inflammation. Growing evidence suggest that proteasome composition and immunoproteasome expression can influence antigen processing. By performing immunopeptidomics on A5...
ORGANISM(S): Homo sapiens (Human) 
2023-03-30 | PXD037365 | Pride
Immunopeptidomics Proteasome Nsclc 
UnknownIndirubin-3'-monoxime acts as proteasome inhibitor: Therapeutic application in multiple myeloma.
Not available
S-EPMC8958548 | biostudies-literature
UnknownA novel blood-based epigenetic biosignature in first-episode schizophrenia patients through automated machine learning.
Not available
S-EPMC11183091 | biostudies-literature
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