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ProteomicsEngineered transfer RNAs for suppression of premature termination codons
PTCs cause a multitude of human diseases and there are no established therapeutic options for their therapeutic management. Herein, we report the high-throughput cloning and identification, characterization and functional analysis of anticodon-edited tRNA which display efficacious PTC reversion in ...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2019-02-11 | PXD012581 | Pride
Anticodon edited trnas Ptc repair Ace-trnas 
TranscriptomicsRNA-seq of K1 papillary thyroid cancer (PTC) cell with different TSC22D1 overexpression status
RNA sequencing was performed on K1 papillary thyroid cancer (PTC) cells to investigate the biological function of TSC22D1 variant 2 overexpression. Cells were transfected with the TSC22D1 (NM_006022) Human Tagged ORF Clone, with three empty vector-transfected cells ((TSC22D1_0) serving as negative c...
ORGANISM(S): Homo sapiens 
2025-07-24 | E-MTAB-15253 | biostudies-arrayexpress
TranscriptomicsA genome-wide expression comparison of productive and unproductive airway epithelial repair
Defective epithelial repair in the setting of chronic lung disease has been suggested to contribute to uncontrolled extracellular matrix (ECM) deposition and development of fibrosis. We sought to directly test this hypothesis through gene expression profiling of total lung RNA isolated from mouse mo...
ORGANISM(S): Mus musculus 
2009-08-18 | E-GEOD-17693 | biostudies-arrayexpress
UnknownThe BMI1 inhibitor PTC-209 is a potential compound to halt cellular growth in biliary tract cancer cells.
Not available
S-EPMC4808030 | biostudies-literature
TranscriptomicsExpression changes in Caenorhabditis elegans xpa-1 mutant
Background: The ability of an organism to repair DNA damage is implicated in carcinogenesis and aging. Interestingly expression profiling of Nucleotide Excision Repair (NER) deficient segmental progeroid mice revealed gene expression changes resembling these observed in aged wild type animals. Our p...
ORGANISM(S): Caenorhabditis elegans 
2013-05-03 | E-GEOD-39252 | biostudies-arrayexpress
UnknownBmi1 inhibitor PTC-209 promotes Chemically-induced Direct Cardiac Reprogramming of cardiac fibroblasts into cardiomyocytes.
Not available
S-EPMC7189257 | biostudies-literature
TranscriptomicsGene expression changes in a histone sprocket arginine mutant in histone H2A R78A
Examined gene expression changes in a histone H2A R78A mutant in Saccharomyces cerevisiae relative to wild-type cells. THe overall goal of this study was to determine the functions of histone 'sprocket' arginine residues, which insert into the DNA minor groove in the nucleosome. We examined the role...
ORGANISM(S): Saccharomyces cerevisiae 
2015-08-05 | E-GEOD-68159 | biostudies-arrayexpress
TranscriptomicsComparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways
The mammalian heart has poor regenerative capacity following injury. In contrast, certain lower vertebrates such as zebrafish retain a robust capacity for regeneration into adult life. Here we use an integrated approach to identify evolutionary conserved regenerative miRNA-dependant regulatory circu...
ORGANISM(S): Mus musculus 
2016-02-15 | E-GEOD-51012 | biostudies-arrayexpress
TranscriptomicsComparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways
The mammalian heart has poor regenerative capacity following injury. In contrast, certain lower vertebrates such as zebrafish retain a robust capacity for regeneration into adult life. Here we use an integrated approach to identify evolutionary conserved regenerative miRNA-dependant regulatory circu...
ORGANISM(S): Danio rerio 
2016-02-18 | E-GEOD-51013 | biostudies-arrayexpress
TranscriptomicsComparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Danio rerio 
2016-02-15 | E-GEOD-51014 | biostudies-arrayexpress
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