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GenomicsGenome-wide binding pattern of PU.1 in normal erythroid progenitors and erythroleukemia cells
We find that the myeloid master regulatory transcription factor, PU.1, binds to >16,000 sites in both normal and leukemic erythroid cells. Of these bound sites, ~7,000 lie within 2kb of TSS of a gene, suggesting PU.1 may regulate a large number of genes in erythroid cells. Coupling this data with ge...
ORGANISM(S): Mus musculus 
2011-06-23 | E-GEOD-21950 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse erythroleukemia cells following activation of Gata1-ER or PU.1-ER transgenes
17b-Estradiol added to MEL cells expressing Gata1-ER or PU.1-ER transgenes to stimulate either erythropoietic Gata-1 dependent or myeloid PU.1 dependent gene espression in different time points
ORGANISM(S): Mus musculus 
2009-09-30 | E-MTAB-125 | biostudies-arrayexpress
GenomicsCell-Specific Determinants of PPARg Function in Adipocytes and Macrophages
The nuclear receptor Peroxisome Proliferator Activator Receptor (PPAR ) is the target of antidiabetic thiazolidinedione drugs, which improve insulin resistance but have side-effects that limit widespread use. PPAR is required for adipocyte differentiation, but is also expressed in other cell type...
ORGANISM(S): Mus musculus 
2010-04-14 | E-GEOD-21314 | biostudies-arrayexpress
GenomicsSpi-1/PU.1 activates transcription through clustered DNA occupancy in erythroleukemia
Acute leukemia are characterized by deregulation of transcriptional networks that control the lineage specificity of gene expression. The aberrant overexpression of the Spi-1/PU.1 transcription factor leads to erythroleukemia. To determine how Spi-1 mechanistically influences the transcriptional pro...
ORGANISM(S): Mus musculus 
2012-06-30 | E-GEOD-33611 | biostudies-arrayexpress
TranscriptomicsMacrophage-specific gene functions in Spi1-directed innate immunity
The Spi1/ Pu.1 transcription factor plays a crucial role in myeloid cell development across many species. Several Spi1 target genes have been identified so far, yet the Spi1-dependent gene group remains largely unknown. To identify novel genes downstream of Spi1 we employed a microarray strategy usi...
ORGANISM(S): Danio rerio 
2010-04-30 | E-GEOD-19206 | biostudies-arrayexpress
GenomicsPruning of the adipocyte cistrome by hematopoietic master regulator PU.1 (ChIP-seq)
"Master" transcription factors are the gatekeepers of lineage identity. As such, they have been a major focus of efforts to manipulate cell fate for therapeutic purposes. The ETS transcription factor PU.1 has a potent ability to confer macrophage phenotypes on cells already committed to a ...
ORGANISM(S): Mus musculus 
2013-06-27 | E-GEOD-48343 | biostudies-arrayexpress
GenomicsCo-regulation of transcription factor binding and nucleosome occupancy through DNA features of mammalian enhancers
In mammalian cells transcription factors (TFs) preferentially bind sites contained in regions of high nucleosomal occupancy, as determined by nucleotide-dependent computational analysis. This observation suggests that nucleosomes may act as gatekeepers of TF binding sites. We hypothesized that in ma...
ORGANISM(S): Mus musculus 
2014-05-08 | E-GEOD-50762 | biostudies-arrayexpress
GenomicsRemodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription
Recent studies suggest a hierarchical model in which lineage-determining factors act in a collaborative manner to select and prime cell-specific enhancers, thereby enabling signal-dependent transcription factors to bind and function in a cell type-specific manner. Consistent with this model, TLR4 si...
ORGANISM(S): Mus musculus 
2013-08-09 | E-GEOD-48759 | biostudies-arrayexpress
GenomicsSPIB and BATF provide alternate determinants of IRF4 occupancy in Diffuse Large B-cell Lymphoma linked to disease heterogeneity
ChIP-seq data for the transcription factors (TFs) IRF4, PU.1 and SPIB from the cell lines OCI-LY3, OCI-LY10 and H929, and BATF from the cell lines OCI-Ly3 and OCI-Ly10. In addition ChIP-seq for the TFs IRF4, PU.1 and SPIB from the cell line OCI-LY3 following transfections of scramble/SPIB-siRNA. ChI...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-56857 | biostudies-arrayexpress
UnknownInactivation of PU.1 in adult mice leads to the development of myeloid leukemia.
Not available
S-EPMC1360594 | biostudies-literature
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