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MetabolomicsPu-erh tea and theabrownin ameliorate metabolic syndrome in mice via potential microbiota-gut-liver-brain interactions
Metabolic syndrome (MS) is a common metabolic disorder characterized by obesity, insulin resistance, cardiovascular disease and gut microbiota dysbiosis. Pu-erh tea and its ingredient theabrownin have known functions on the reduction of body weight gain and fat accumulation. However, few studies sys...
2024-09-25 | MTBLS2594 | MetaboLights
MetabolomicsTheabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism
Pu-erh tea displays cholesterol-lowering properties, but the underlying mechanism has not been elucidated. Theabrownin is one of the most active and abundant pigments in Pu-erh tea. Here, we show that theabrownin alters the gut microbiota in mice and humans, predominantly suppressing microbes associ...
2021-11-18 | MTBLS1259 | MetaboLights
GenomicsTwo distinct auto-regulatory loops operate at the Pu.1 locus in B cells and myeloid cells
The transcription factor PU.1 occupies a central role in controlling myeloid and early B cell development and its correct lineage-specific expression is critical for the differentiation choice of hematopoietic progenitors. However, little is known of how this tissue-specific pattern is established. ...
ORGANISM(S): Mus musculus 
2011-02-21 | E-GEOD-26550 | biostudies-arrayexpress
UnknownThe role of a key transcription factor PU.1 in autoimmune diseases.
Not available
S-EPMC9557192 | biostudies-literature
UnknownPositive feedback loop PU.1-IL9 in Th9 promotes rheumatoid arthritis development.
Not available
S-EPMC11672030 | biostudies-literature
ProteomicsA systemic view of microbial ecology in spontaneous fermentation of Chinese traditional pu-erh tea
To study the microbial functions, metaproteomes were extracted from 36 samples of fermented tea leaves and subjected to LC-MS/MS analyses. The MS/MS data were searched against the UniProt-protein database of the dominant microorganisms in the sample as identified by previous meta-barcoding analysis....
ORGANISM(S): Aspergillus Thermomyces Rasamsonia 
2019-01-03 | PXD012223 |
UnknownA Systemic Insight into Exohedral Actinides and Endohedral Borospherenes: An&Bm and An@Bn (An=U, Np, Pu; m = 28, 32, 34, 36, 38, 40; n = 36, 38, 40).
Not available
S-EPMC9500945 | biostudies-literature
ProteomicsIdentification of LC3-binding proteins on lipid droplets
In the search for LD-localized proteins that may mediate lipophagy, we purified LDs from HeLa cells treated with oleic acid (OA), which stimulates LD biogenesis and lipophagy, together with chloroquine (CQ), which inhibits lysosomal degradation. We incubated the LD lysates with purified GST-LC3B, an...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD036200 | Pride
Lipid droplet Lc3 
ProteomicsIdentification of phosphorylation sites of HA-ORP8 immunoprecipitated from cells
To candidate phosphorylation sites of ORP8 in cells and the stoichiometric change of ORP8's phosphorylation when AMPK is activated,LC-MS/MS analysis of ORP8 immunoprecipitated from serum-starved cells and cells treated with AMPK activator AICAR was performed.
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD036204 | Pride
Phosphorylation Orp8 
ProteomicsIdentification of phosphorylation sites of purified ORP8 from in vitro AMPK kinase assay
We investigated the potential role of AMPK in the phosphorylation of ORP8.In vitro kinase assay using purified ORP8 and kinase-active AMPK complex confirmed that ORP8 is the direct substrate of AMPK. Phosphorylated ORP8 from in vitro kinase assay was analyzed by HPLC-MS/MS.
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD036201 | Pride
Ampk Phosphorylation Orp8 
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