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Hypothalamic hamartomas (HHs) are congenital lesions of the neuroendocrine brain composed of neurons and astroglia. Frequently, HHs are associated with central precocious puberty (CPP) and/or gelastic seizures. Because HHs might express genes similar to those required for the initiation of normal pu...
ORGANISM(S): Homo sapiens 
The present study aims to investigate changes in genomic DNA methylation profiles associated with pubertal onset analysing human peripheral blood leucocytes from three different groups of subjects: central precocious puberty (CPP), healthy prepubertal girls matched by age (CTPP), and healthy puberta...
ORGANISM(S): Homo sapiens 
Mutations in the E3 ubiquitin ligase Mkrn3 are associated with precocious puberty in humans. In order to determine the targets of Mkrn3, we performed a TMT-based proteomic analysis of Mkrn3 WT vs KO mouse brains.
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD027220 | Pride
Puberty unmasks or accelerates nephropathies, including the nephropathy of diabetes mellitus (DM). A number of cellular systems implicated in the kidney disease of DM interweave, forming an interdependent functional web. We performed focused microarray analysis to test the hypothesis that one or mor...
ORGANISM(S): Rattus norvegicus 
Identification of puberty related miRNAs in the hypothalamus of female mice
The Dynamic Transcriptional Cell Atlas of Testis Development During Human Puberty
DNA methylomes of pituitaries during the onset of puberty in gilts
DNA methylomes of hypothalamus during the onset of puberty in gilts
To better understand the epigenetic mechanism underlying pubertal onset, the hypothalamic genome-wide chromatin accessibility patterns in mouse arcuate nucleus at early and late pubertal stages were explored. Female mice have been widely used in multiple studies on pubertal development as they prese...
ORGANISM(S): Mus musculus 
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