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GenomicsThe DNA methylomes of a newborn and a centenarian
We have developed Whole Genome Bisulfite Sequencing (WGBS) of a newborn and a centenarian to address the epigenetic drifts in human aging, which might be an alternative pathway to explain the age-associated alterations. In addition, we have analyzed the methylome of a middle-age donor (26 years). Ex...
ORGANISM(S): Homo sapiens 
2012-06-13 | E-GEOD-31263 | biostudies-arrayexpress
TranscriptomicsGenome-wide CpG methylation during osteogenic and myogenic differentiation from adipose- derived stem cells.
In the current study, we have performed a high-throughput CpG methylation analysis of well characterized and defined populations of human adipose-derived stem cells (hASCs) before and after in vitro induction of osteogenic and myogenic differentiation that allows identifying DNA methylation- regulat...
ORGANISM(S): Homo sapiens 
2014-01-02 | E-GEOD-33896 | biostudies-arrayexpress
TranscriptomicsGene expression in cells encapsulated within different types of alginate microcapsules
D1 multipotent mesenchymal stromal cells (D1‐MSCs,ATCC® CRL 12424TM) and genetically modified with the lentiviral vector pSIN‐EF2‐Epo‐Pur to express erythropoietin (EPO). D1‐MSCs genetically modified to release EPO were immobilized into 3D alginatepoly‐ L‐lysine‐alginate (APA) microcapsules. Since d...
ORGANISM(S): Mus musculus 
2017-10-30 | E-MTAB-5786 | biostudies-arrayexpress
TranscriptomicsThe DNA Methylomes of a Newborn and a Centenarian
Examination of two DNA methylomes at the most extreme points of their lives to see differences that might contribute to explain the aged phenotype We have performed Whole Genome Bisulfite Sequencing (WGBS) and methylation array technology of newborn and a centenarian samples to address the Epigeneti...
ORGANISM(S): Homo sapiens 
2012-07-10 | E-GEOD-31438 | biostudies-arrayexpress
UnknownAgnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer.
Not available
S-EPMC6579744 | biostudies-literature
UnknownMultifunctional biomimetic hydrogel systems to boost the immunomodulatory potential of mesenchymal stromal cells.
Not available
S-EPMC7477339 | biostudies-literature
UnknownFas-activated serine/threonine phosphoprotein (FAST) is a regulator of alternative splicing.
Not available
S-EPMC2040905 | biostudies-literature
TranscriptomicsDNA methylation differences between Newborns and Nonagenarians [PBMNC]
Human aging implies many phenotypic modifications and an increased susceptibility to many common diseases, phenomena that cannot be fully explained by the constrained genetic setting. An alternative pathway that could explain the age-associated alterations is epigenetic drifts. To address this issue...
ORGANISM(S): Homo sapiens 
2012-06-12 | E-GEOD-33233 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of BRCA1-mutated breast tumors
Background: Breast cancer is a complex disease, encompassed by different clinically and molecularly stratified entities. In 2000, Perou and colleagues demonstrated that tumor phenotypic diversity correlates with differences in global gene expression patterns, which in turn reflect aspects of the bio...
ORGANISM(S): Homo sapiens 
2009-10-14 | E-GEOD-12350 | biostudies-arrayexpress
TranscriptomicsDNA methylomes of Newborns and Nonagenarians
DNA methylation differences between Newborns and Nonagenarians The study aimed to compare the DNA methylation differences between newborns and nonagenarians using methylation array technology (450K, Illumina). The identified differently methylated CpG were further analyzed for their presence in dise...
ORGANISM(S): Homo sapiens 
2012-06-12 | E-GEOD-30870 | biostudies-arrayexpress
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