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MetabolomicsPKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis
Metabolic reprogramming is a hallmark of cancer. Herein we discover that the key glycolytic enzyme pyruvate kinase M2 isoform (PKM2), but not the related isoform PKM1, is methylated by co-activator-associated arginine methyltransferase 1 (CARM1). PKM2 methylation reversibly shifts the balance of met...
2021-07-30 | MTBLS533 | MetaboLights
TranscriptomicsExpression data from PKM1 or PKM2 expressing mouse embryonic fibroblasts.
We profiled global gene expression for two separate lines of mouse embryonic fibroblasts and find that deletion of PKM2 and expression of PKM1 does not alter global gene expression profiles. We used microarrays to futher characterize the effects of PKM1 expression compared to PKM2 expression on glob...
ORGANISM(S): Mus musculus 
2015-05-01 | E-GEOD-60499 | biostudies-arrayexpress
ProteomicsPyruvate kinase M2 modification by a lipid peroxidation byproduct acrolein contributes to kidney fibrosis
This study used a proteomic approach with an anti-Acr-PC antibody followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis to identify several acrolein-modified protein targets. Among these protein targets, pyruvate kinase M2 (PKM2) was found to be modified by acrolein at Cys35...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD040335 | Pride
Renal fibrosis  acrolein  pyruvate kinase m2  hypoxia-inducible factor 1-alpha  hydralazine  carnosine. 
ProteomicsHydrogen Sulfide Coordinates Glucose Metabolism Switch through Destabilizing Tetrameric Pyruvate Kinase M2
Cancer cells reprogram their glucose metabolic pathway from oxidative phosphorylation toward aerobic glycolysis. Pyruvate kinase M2 (PKM2), which converts phosphoenolpyruvate (PEP) to pyruvate, is considered the rate-limiting enzyme involved in cancer glucose metabolism. By reducing PKM2 enzyme acti...
ORGANISM(S): Homo sapiens (Human) 
2024-07-09 | PXD044925 | Pride
Glucose metabolism Pkm2 Lc-ms Oligomerization Sulfhydration Hydrogen sulfide 
TranscriptomicsExpression profiling of E14 cells overexpressing Hk2/Pkm2
Purpose: In this study, we compared transcriptome profiling (RNA-seq) between normal mouse embryonic stem cell (E14) and Hexokinase2 (Hk2)/ Pyruvate Kinase M2 (Pkm2) overexpressed E14 cell. Result: Using an optimized data analysis workflow, we mapped over 4 billion sequence reads per sample to the m...
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-65246 | biostudies-arrayexpress
ProteomicsSUMOylation disassembles the tetrameric pyruvate kinase M2 to block myeloid differentiation of leukemia cells
Leukemia arises from blockage of the differentiation/maturation of hematopoietic progenitor cells at different stages with uncontrolled proliferation of leukemic cells. However, the signal pathways that block cell differentiation remain unclear. Herein we found that SUMOylation of the M2 isoform of ...
ORGANISM(S): Homo Sapiens 
2020-12-26 | PXD023317 |
GenomicsPyruvate Kinase M2 Regulates Photoreceptor Neuroprotection
Pyruvate Kinase M2 Regulates Photoreceptor Neuroprotection
PRJNA1125309 | ENA
GenomicsPharmacological activation of pyruvate kinase M2 (PKM2) inhibits CD4+ T cell pathogenicity and suppresses autoimmunity
Pharmacological activation of pyruvate kinase M2 (PKM2) inhibits CD4+ T cell pathogenicity and suppresses autoimmunity
PRJNA579507 | ENA
ProteomicsPKM2 functions as a histidine kinase to phosphorylate PGAM1 to increase glycolysis shunts in cancer
Phosphoglycerate mutase 1 (PGAM1) is a key-node enzyme that diverts the metabolic intermediates from glycolysis into its shunts to support macromolecule biosynthesis for rapid and sustainable cell proliferation. It is prevalent that PGAM1 activity is upregulated in various tumors; however, the under...
ORGANISM(S): Homo sapiens (Human) 
2024-03-21 | PXD049235 | Pride
Glycolysis shunts Pyruvate kinase m2 (pkm2) Histidine kinase Phosphorylation Phosphoglycerate mutase 1 (pgam1) 
ProteomicsPKM2 functions as a histidine kinase to phosphorylate PGAM1 to increase glycolysis shunts in cancer-Cellular lipid level assessment
Phosphoglycerate mutase 1 (PGAM1) is a key node enzyme that diverts the metabolic reactions from glycolysis into its shunts to support macromolecule biosynthesis for rapid and sustainable cell proliferation. It is prevalent that PGAM1 activity is upregulated in various tumors; however, the underlyin...
ORGANISM(S): Homo sapiens (Human) 
2024-03-21 | PXD049310 | Pride
Glycolysis shunts Pyruvate kinase m2 (pkm2) Histidine kinase Phosphorylation Phosphoglycerate mutase 1 (pgam1) 
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