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ProteomicsUltraviolet Photodissociation of ESI and MALDI generated protein ions on a Q-Exactive mass spectrometer
UVPD was implemented on an Orbitrap Q-Exactive plus equipped with a ESI/EP-MALDI. UVPD of MALDI generated ions was benchmarked against MALDI-ISD, MALDI-HCD and ESI-UVPD. MALDI UVPD outperformed MALDI HCD and ISD efficiently sequencing small proteins ions.
ORGANISM(S): Homo sapiens (Human) Equus caballus (Horse) 
2019-01-24 | PXD011526 | Pride
Ms/ms Uvpd Q-exactive Maldi 
ProteomicsThe Q Exactive HF, a Benchtop Mass Spectrometer with a Pre-filter, High Performance Quadrupole and an Ultra-High Field Orbitrap Analyzer
The quadrupole Orbitrap mass spectrometer (Q Exactive) has made a powerful proteomics instrument available in a benchtop format. It significantly boosted analyzable proteins per hour and has now evolved into a proteomics analysis workhorse for many laboratories. Here we describe the Q Exactive Plus ...
ORGANISM(S): Homo sapiens (Human) 
2014-11-10 | PXD001203 | Pride
Segmented quadrupole Q exactive hf Orbitrap ultra-high field Q exactive plus Quadrupole pre-filter Shotgun proteomics 
MetabolomicsA novel targeted/untargeted GC-Orbitrap metabolomics methodology applied to Candida albicans and Staphylococcus aureus biofilms

INTRODUCTION: Combined infections from Candida albicans and Staphylococcus aureus are a leading cause of death in the developed world. Evidence suggests that Candida enhances the virulence of Staphylococcus - hyphae penetrate through tissue bar...

2017-02-20 | MTBLS370 | MetaboLights
UnknownImmunodepletion plasma proteomics by tripleTOF 5600 and Orbitrap elite/LTQ-Orbitrap Velos/Q exactive mass spectrometers.
Not available
S-EPMC3817719 | biostudies-literature
MetabolomicsMetabolic and gut microbial remodeling in captive Amur tigers under uniform feeding

Ultra-high-performance liquid chromatography (UHPLC) was conducted using a Vanquish UHPLC system (Thermo Fisher), coupled with a Q Exactive™ HF/Q Exactive™ HF-X mass spectrometer for liquid chromatography-mass spectrometry (LC-MS) analysis. To ensure...

2026-06-05 | MTBLS14159 | MetaboLights
MetabolomicsA thioredoxin-Serinc2-lipid signaling axis modulates mood-related behaviors in mice
Bipolar disorder (BD) shows strong heritability and distinct symptomatic subtypes. However, the molecular basis underlying subtype-specific features remains poorly understood. Here, we showed that Serinc2, a BD susceptibility gene encoding a L-serine transporter that regulates membrane lipid synthes...
2026-07-06 | MTBLS14954 | MetaboLights
UnknownThe Q Exactive HF, a Benchtop mass spectrometer with a pre-filter, high-performance quadrupole and an ultra-high-field Orbitrap analyzer.
Not available
S-EPMC4256516 | biostudies-literature
MetabolomicsMulti-Omics Unveils Strain-Specific Neuroactive Metabolite Production Linked to Inflammation Modulation by Bacteroides and Their Vesicles

18 Bacteroidetes isoaltes were analyzed for their neuroactive potentail using un-targeted and targeted metabolomics. The bacteria were grown to stationary phase, the supernatant was separated and purified using 0.22 um filter. The metabolome from the supernatant was extracted using standard Metha...

2025-08-12 | MTBLS10526 | MetaboLights
UnknownA Systematic Method for the Identification of Aporphine Alkaloid Constituents in Sabia schumanniana Diels Using UHPLC-Q-Exactive Orbitrap/Mass Spectrometry.
Not available
S-EPMC9656101 | biostudies-literature
MetabolomicsMicroglia contributes to bipolar depression through Serinc2-dependent phospholipid synthesis

Although clinical research has revealed microglia-related inflammatory and immune responses in bipolar disorder (BD) patient brains, it remains unclear how microglia contribute to the pathogenesis of BD. Here, we demonstrated that Serinc2 is associated with susceptibility to BD and showed a reduc...

2025-08-27 | MTBLS12830 | MetaboLights
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