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ProteomicsSubcellular Proteomic Analyses Reveal REEP5 Knockdown in the Mouse Heart Disrupts Mitochondrial Networks
This study investigates the role of REEP5 in maintaining organelle integrity and redox homeostasis in cardiac tissue (specifically cardiomyocytes). Using AAV9-mediated shRNA knockdown in postnatal mice, we acheived a cardiac-specific depletion of REEP5. Hearts were harvested 4 weeks post-injection a...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-30 | PXD065280 | Pride
ProteomicsProteome Analysis from a Multispanning Transmembrane Gene COR413-PM1 in Arabidopsis
Proteomic Analysis of the Arabidopsis wild-type and cor413-pm1 seedlings under control and freezing treatment.
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2018-09-05 | PXD010031 | Pride
Cold stress Arabidopsis Q-excative plus 
MetabolomicsEpithelial-Cell-Derived Phospholipase A2 Group 1B Is an Endogenous Anthelmintic
Immunity to intestinal helminth infections has been well studied, but the mechanism of helminth killing prior to expulsion remains unclear. Here we identify epithelial-cell-derived phospholipase A2 group 1B (PLA2g1B) as a host-derived endogenous anthelmintic. PLA2g1B is elevated in resistant mice an...
2018-08-13 | MTBLS523 | MetaboLights
ProteomicsProteomic and phosphoproteomic changes in C.elegans embryo as a result of pig-1 mutation
Comparison of the proteome and phosphoproteome of wild type C.elegans embryos compared to pig-1 mutant embryos
ORGANISM(S): Caenorhabditis elegans 
2017-12-11 | PXD005752 | Pride
Embryo Phosphoproteome Development C.elegans 
ProteomicsIdentification of tumor antigens in the HLA peptidome of patient-derived xenograft tumors in mouse
Personalized cancer immunotherapy targeting patient-specific cancer/testis (CTA) antigens and neoantigens may benefit from large-scale tumor HLA peptidome (immunopeptidome) analysis, which aims to accurately identify antigens presented by tumor cells. While significant efforts have been invested in ...
ORGANISM(S): Homo sapiens (Human) 
2020-05-27 | PXD016060 | Pride
Patient derived xenograft Tumor antigen Peptidome Hla 
ProteomicsChemical cross-linking mass spectrometry for systems structural biology in mouse heart tissue.
While modern structural biology technologies have greatly expanded the size and type of protein complexes that can now be studied, the ability to derive large-scale structural information on proteins and complexes as they exist within tissues is practically non-existent. Many protein properties and...
ORGANISM(S): Mus musculus (Mouse) 
2017-11-30 | PXD007673 | Pride
Mass spectrometry Structural biology Mouse Heart Protein-protein interactions Cross-linking 
ProteomicsCorneal protome of trangenic TGFBI R124H mouse model
In this study we analysed the proteome of transforming growth factor β-induced protein (TGFBIp) R124H transgenic mouse corneas in an attempt to understand the disease mechanisms leading to the granular corneal dystrophy type 2. The transgenic mouse model was generated by insertion of human TGFBI cDN...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-10-20 | PXD012902 | Pride
Mouse Cornea Lc-ms/ms 
ProteomicsGID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme
How are E3 ubiquitin ligases configured to match substrate quaternary structures? Here, by studying the yeast GID complex, mutation of which is Glucose-Induced Degradation deficient, we discover supramolecular chelate assembly as an E3 ligase strategy for targeting an oligomeric substrate. Cryo EM s...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-04-28 | PXD024462 | Pride
Supramolecular assembly Metabolism Gluconeogenesis Cryo em E3 ligase Gid Ubiquitin Ctlh 
ProteomicsCellular interactome dynamics during paclitaxel treatment
Cell cycle inhibitors, including paclitaxel, are among the most widely used and effective cancer therapies. However, several challenges limit the success of paclitaxel including drug resistance and toxic side effects. Paclitaxel is thought to act primarily by stabilizing microtubules and locking cel...
ORGANISM(S): Homo sapiens (Human) 
2019-11-21 | PXD015751 | Pride
Mitotic inhibitor Chemical cross-linking 
ProteomicsA systematic comparison of label-free, SILAC and TMT techniques to study early adaption towards inhibition of EGFR signaling in the colorectal cancer cell line Difi
The epithelial growth factor receptor (EGFR) signalling network plays an essential role inproliferation and survival of colorectal cancer cells. For this reason, EGFR is targeted using therapeutic antibodies blocking EGFR signalling (e.g. cetuximab). However, anti-EGFR therapy is rarely curative as ...
ORGANISM(S): Homo sapiens (Human) 
2019-12-11 | PXD014565 | Pride
Phosphoproteomics Tmt Anti-egfr therapy Colorectal cancer Silac Mapk Label-free Erbb3 Adaptive mechanism Cetuximab 
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