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MetabolomicsGluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei
Bloodstream form African trypanosomes are thought to rely exclusively upon glycolysis, using glucose as a substrate, for ATP production. Indeed, the pathway has long been considered a potential therapeutic target to tackle the devastating and neglected tropical diseases caused by these parasites. Ho...
2018-12-10 | MTBLS706 | MetaboLights
MetabolomicsDynamics of metabolism, proliferation and differentiation in Toxoplasma gondii mutants deficient in glycolysis and gluconeogenesis
Not available
ORGANISM(S): Toxoplasma gondii 
ST000817 | MetabolomicsWorkbench
ProteomicsDYRK1B phosphorylates FOXO1 to promote hepatic gluconeogenesis
Dual-specificity tyrosine phosphorylation-regulated kinase 1B (DYRK1B), a member of the CMGC group of kinase, is associated with metabolic syndrome. However, the molecular mechanisms involved remain elusive. In this study, we demonstrate that Dyrk1b expression is induced in liver by fasting and in d...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD052214 | Pride
Dyrk1b Diabetes Foxo1 Gluconeogenesis Phosphorylation 
TranscriptomicsTranscription profiling of mouse livers and quadriceps muscles of Kruppel-like factor 15 (KLF15) null mutants after an overnight fast to provide insight into the role of KLF15 in gluconeogenesis
We used microarray analysis to identify differences in gene expression levels, in liver and in quadriceps skeletal muscle, between 18h (overnight) fasted WT control and Kruppel-like factor 15 (KLF15)-null mice. Experiment Overall Design: Liver and skeletal muscle (quadriceps) tissues were isolated f...
ORGANISM(S): Mus musculus 
2007-11-07 | E-GEOD-7137 | biostudies-arrayexpress
ProteomicsLkb1 suppresses amino acid-driven gluconeogenesis in the liver
Excessive glucose production in the liver is a key factor in the hyperglycemia observed in diabetes mellitus type 2. It is generally agreed to result from an increase in hepatic gluconeogenesis. Considerable attention has been devoted to the transcriptional regulation of key gluconeogenic enzymes, b...
ORGANISM(S): Mus musculus (Mouse) 
2020-12-01 | PXD019757 | Pride
Gluconeogenesis Phosphoproteome Sarcopenia Liver Cachexia Q-exactive Label-free quantification Amino acids Lkb1 Orbitrap fusion 
ProteomicsLkb1 suppresses amino acid-driven gluconeogenesis in the liver
Excessive glucose production in the liver is a key factor in the hyperglycemia observed in diabetes mellitus type 2. It is generally agreed to result from an increase in hepatic gluconeogenesis. Considerable attention has been devoted to the transcriptional regulation of key gluconeogenic enzymes, b...
ORGANISM(S): Mus musculus (Mouse) 
2020-12-01 | PXD019755 | Pride
Gluconeogenesis Phosphoproteome Sarcopenia Liver Cachexia Q-exactive Label-free quantification Amino acids Lkb1 Orbitrap fusion Refed mice 
ModelsBae2017 - Mathematical analysis of circadian disruption and metabolic re-entrainment of hepatic gluconeogenesis
The circadian rhythms influence the metabolic activity from molecular level to tissue, organ, and host level. Disruption of the circadian rhythms manifests to the host's health as metabolic syndromes, including obesity, diabetes, and elevated plasma glucose, eventually leading to cardiovascular dise...
2024-09-02 | BIOMD0000001005 | BioModels
ProteomicsLKB1 is a suppressor of amino acid-driven gluconeogenesis in the liver
Excessive hepatic glucose production is a major contributor to the hyperglycemia observed in Type 2 diabetes mellitus. It is widely accepted that it is due to an increase in hepatic gluconeogenesis. While much attention has been devoted to the transcriptional regulation of key gluconeogenic enzymes,...
ORGANISM(S): Mus musculus (Mouse) 
2020-12-01 | PXD013478 | Pride
Gluconeogenesis Maxquant Mus musculus Sarcopenia Liver Q-exactive Label-free Amino acids Lkb1 Insulin 
MetabolomicsGlycolysis/gluconeogenesis specialization in microbes is driven by biochemical constraints of flux sensing
Central carbon metabolism is highly conserved across microbial species, but can catalyze very different pathways depending on the organism and their ecological niche. Here, we study the dynamic reorganization of central metabolism after switches between the two major opposing pathway configurations ...
2022-01-11 | MTBLS3887 | MetaboLights
GenomicsDYRK1B phosphorylates FOXO1 to promote hepatic gluconeogenesis
DYRK1B phosphorylates FOXO1 to promote hepatic gluconeogenesis
PRJNA1095472 | ENA
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