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ProteomicsDYRK1B phosphorylates FOXO1 to promote hepatic gluconeogenesis
Dual-specificity tyrosine phosphorylation-regulated kinase 1B (DYRK1B), a member of the CMGC group of kinase, is associated with metabolic syndrome. However, the molecular mechanisms involved remain elusive. In this study, we demonstrate that Dyrk1b expression is induced in liver by fasting and in d...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD052214 | Pride
Dyrk1b Diabetes Foxo1 Gluconeogenesis Phosphorylation 
ProteomicsDYRK1B blockade promotes tumoricidal macrophage activity in pancreatic cancer
Highly malignant pancreatic ductal adenocarcinoma (PDAC) is characterized by an abundant immunosuppressive and fibrotic tumor microenvironment (TME). Future therapeutic attempts therefore demand targeting of both compartments in order to be effective. We show here that Dual Specificity and Tyrosine...
ORGANISM(S): Mus Musculus 
2024-01-02 | MSV000093747 | MassIVE
GenomicsHepatic Dyrk1b regulates whole body glucose homeostasis
Hepatic Dyrk1b regulates whole body glucose homeostasis
PRJNA981190 | ENA
GenomicsDYRK1B phosphorylates FOXO1 to promote hepatic gluconeogenesis
DYRK1B phosphorylates FOXO1 to promote hepatic gluconeogenesis
PRJNA1095472 | ENA
GenomicsDYRK1B phosphorylates FOXO1 to promote hepatic gluconeogenesis
DYRK1B phosphorylates FOXO1 to promote hepatic gluconeogenesis
PRJNA1090398 | ENA
GenomicsHepatic Dyrk1b regulates systemic glucose homeostasis [mouse liver]
Hepatic Dyrk1b regulates systemic glucose homeostasis [mouse liver]
PRJNA996137 | ENA
ProteomicsThe protein kinase DYRK1B is a p53 target gene and functions as a negative feedback regulator of the transcription factor RFX7 - PROTEOME
The tumor suppressor protein p53 orchestrates cellular responses to stress by regulating the transcription of target genes involved in processes such as cell cycle control, DNA damage repair and apoptosis. The protein kinase DYRK1B, known to promote cancer cell survival and contribute to DNA damage ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-13 | PXD067702 | Pride
Dyrk1b Dyrk1a A549 Rfx7 P53 
ProteomicsScreen Identifies DYRK1B Network as Mediator of Transcription Repression on Damaged Chromatin
The uploaded data are described within "Screen Identifies DYRK1B Network as Mediator of Transcription Repression on Damaged Chromatin". In short, peptides from RPE1 epithelial cells with either normal expression of DYRK1B, over expression, of knockout of the kinase were TMT11 plex labeled and enrich...
ORGANISM(S): Homo sapiens (Human) 
2020-06-18 | PXD019102 | Pride
Human Epithelial Tmt Phosphopeptide Cell culture 
GenomicsHepatic Dyrk1b regulates whole body glucose homeostasis by modulating Wbp2 expression
Hepatic Dyrk1b regulates whole body glucose homeostasis by modulating Wbp2 expression
PRJNA980672 | ENA
TranscriptomicsHepatic Dyrk1b regulates whole body glucose homeostasis
Illuminating the mechanisms controlling glucose homeostasis may deepen our understanding of the pathogenesis of T2DM and provide new therapeutic strategies for T2DM in future. As reported, Dyrk1b is a pleiotropic protein and its genetic mutations associate with blood glucose levels. Yet, the role of...
ORGANISM(S): Mus musculus 
2025-05-29 | GSE234405 | GEO
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