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MetabolomicsFunctional Characterization of the Lin28/let-7 Circuit During Forelimb Regeneration in Ambystoma mexicanum and Its Influence on Metabolic Reprogramming
The axolotl (Ambystoma mexicanum) is a caudate amphibian, which has an extraordinary ability to restore a wide variety of damaged structures by a process denominated epimorphosis. While the origin and potentiality of progenitor cells that take part during epimorphic regeneration are known to ...
2021-11-04 | MTBLS1708 | MetaboLights
MetabolomicsMethionine Intervention Induces PD-L1 Expression to Enhance the Immune Checkpoint Therapy Response in MTAP-deleted Osteosarcoma
Osteosarcoma (OS), a malignant bone tumor with limited treatment options, exhibits low sensitivity to immune checkpoint therapy (ICT). Through genomics and transcriptomics analyses, we have identified a subgroup of OS with methylthioadenosine phosphorylase (MTAP) deletion, which contributes to ICT r...
2026-06-09 | MTBLS11985 | MetaboLights
MetabolomicsGlobal metabolomics of fireflies (Coleoptera: Lampyridae) explore metabolic adaptation to fresh water in insects

Aquatic insects are well-adapted to freshwater environments, but metabolic mechanisms of such adaptations, particularly to primary environmental factors (e.g., hypoxia, water pressure, dark light and abundant microbes), are poorly known. Most firefly species (Coleoptera: Lampyridae) are terrestri...

2022-10-03 | MTBLS4987 | MetaboLights
UnknownEssential function of transmembrane transcription factor MYRF in promoting transcription of miRNA lin-4 during C. elegans development.
Not available
S-EPMC11223767 | biostudies-literature
ProteomicsHuman osteosarcoma and adjacent normal tissues
Osteosarcoma is the most common primary bone cancer in children, adolescents and young adults. It is a rare cancer type. To obtain a comprehensive view of protein expression in osteosarcoma, quantitative TMT–MS was performed with six pairs of osteosarcoma specimens and adjacent normal tissue.
ORGANISM(S): Homo sapiens (Human) 
2025-05-13 | PXD038452 | Pride
Human Osteosarcoma Tmt-ms 
MetabolomicsMetabolite signatures of diverse Camellia sinensis tea populations
Tea plants (Camellia sinensis) present an excellent system to study evolution and diversification of specialized metabolites due to their abundance in classes, numbers and contents. A large number of tea cultivars have been cultivated throughout the world not only because of their adaption to differ...
2020-10-05 | MTBLS1405 | MetaboLights
UnknownThe Role of Qi-Stagnation Constitution and Emotion Regulation in the Association Between Childhood Maltreatment and Depression in Chinese College Students.
Not available
S-EPMC9114459 | biostudies-literature
UnknownOverexpression of WRINKLED1 improves the weight and oil content in seeds of flax (Linum usitatissimum L.).
Not available
S-EPMC9562325 | biostudies-literature
ProteomicsQuantitative proteomics revealed the mechanism of Yiqi Huoxue recipe used to treat cerebral infarction with Qi deficiency and blood stasis
Huoxue Yiqi (HXYQ) recipe is widely used to treat cerebral infarction with Qi deficiency and blood stasis syndrome (CI-QDBS), but its pharmacological mechanism is still not clear. In this study, the serum samples of patients with Qi deficiency and blood stasis syndrome in the convalescent stage of c...
ORGANISM(S): Homo Sapiens 
2022-12-12 | PXD029388 |
ProteomicsHRD1 IP-MS in WT and SEL1L deficiency HEK293T cells
To gain further insights into the role and importance of SEL1L in HRD1 ERAD, we performed unbiased proteomics LC-MS analyses to map SEL1L and HRD1 interactomes in WT and SEL1L-/-, WT and HRD1-/- HEK293T cells, respectively.
ORGANISM(S): Homo sapiens (Human) 
2024-01-10 | PXD043674 | Pride
Erad complex formation Sel1l-hrd1 erad Hek293t 
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