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MetabolomicsBased on untargeted metabolomics and metagenomics: a study on the mechanism of Miao ethnomedicine Zingiber mioga (Thunb.) Rosc. in treating slow transit constipation

A rat model of slow transit constipation (STC) was induced by loperamide hydro-chloride to explore the therapeutic mechanism of Zingiber mioga (Thunb.) Rosc. (RH) using integrated metabolomic and metagenomic approaches. Thirty-six Sprague–Dawley (SD) rats were randomly assigned to 6 gro...

2026-02-11 | MTBLS13888 | MetaboLights
UnknownThe Anti-Inflammatory Effects of Invigorating Kidney and Supplementing Qi Chinese Herbal Formulae in Asthma Patients.
Not available
S-EPMC5504930 | biostudies-literature
ProteomicsQuantitative proteomics revealed the mechanism of Yiqi Huoxue recipe used to treat cerebral infarction with Qi deficiency and blood stasis
Huoxue Yiqi (HXYQ) recipe is widely used to treat cerebral infarction with Qi deficiency and blood stasis syndrome (CI-QDBS), but its pharmacological mechanism is still not clear. In this study, the serum samples of patients with Qi deficiency and blood stasis syndrome in the convalescent stage of c...
ORGANISM(S): Homo Sapiens 
2022-12-12 | PXD029388 |
MetabolomicsMycelium of Diaporthe nobilis treated with 2% cell-free supernatant (CFS) from Bacillus velezensis A4 for 12 hours

Mycelia of Diaporthe nobilis(50 mg) treated with CFS were collected,Each sample was homogenized in 400 µL of pre-cooled 80% methanol aqueous solution containing 0.02 mg/mL L-2-chlorophenylalanine (internal standard). The mixture was ground and subjected to ultrasonication at 4 °C for 30 min. Afte...

2025-11-19 | MTBLS13351 | MetaboLights
UnknownTargeting transcription factors through an IMiD independent zinc finger domain
Not available
S-SCDT-10_1038-S44321-025-00241-3 | biostudies-other
ProteomicsDiscovery of TBC1D7 as a potential driver for melanoma cell invasion.
Melanoma is a common type of cancer, and metastasis remains the leading cause for mortality in melanoma patients. In this study, we utilized an unbiased mass spectrometry-based quantitative proteomic method to assess, at the global proteome scale, differential protein expression in a matched pair of...
ORGANISM(S): Homo sapiens (Human) 
2022-08-15 | PXD014368 | Pride
Tbc1d7 Tbc domain-containing proteins Mass spectrometry Silac Melanoma metastasis Quantitative proteomics 
ProteomicsTargeted Profiling of Epitranscriptomic Reader, Writer and Eraser Proteins in Radioresistant Breast Cancer Cells
Epitransciptomic reader, writer and eraser (RWE) proteins recognize, install, and remove modified nucleosides in RNA, which are known to play essential roles in RNA processing, splicing, and stability. Here, we established a liquid chromatography–parallel reaction monitoring (LC-PRM) method for high...
ORGANISM(S): Homo sapiens (Human) 
2022-08-15 | PXD030387 | Pride
Epitransciptomic reader Lc-prm Radioresistant breast cancer Trmt1 Writer and eraser (rwe) proteins 
ProteomicsProteomic data for tumor pericytes with TCFA2 overexpression
This study aims to investigate differentially expressed proteins in tumor pericytes with or without TCAF2-ovexpression. Tumor pericytes were isolated from tumor of patients with colorectal cancer. Then, tumor pericytes were cultured, transfected with vector or TCAF2 overexpressing plasmid. Top ten c...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD032935 | Pride
Tcaf2 Tumor pericytes 
ProteomicsTargeted Quantitative Profiling of Epitranscriptomic Reader, Writer and Eraser Proteins in Colorectal Cancer Metastasis
Epitranscriptomic reader, writer and eraser (RWE) proteins are involved in the recognition, installation, and removal, respectively, of chemical modifications in RNA, and aberrant expressions of some of these proteins were found to be associated with cancer initiation and progression. Here, we our r...
ORGANISM(S): Homo sapiens (Human) 
2022-08-15 | PXD030907 | Pride
Epitranscriptomic reader Prm Colorectal cancer metastasis Writer and eraser proteins 
MetabolomicsUPLC-QTOF-MS-Based Plasma Lipidomic Profiling Reveals Biomarkers for Inflammatory Bowel Disease Diagnosis
Identification of new biomarkers may help in the early diagnosis of inflammatory bowel disease (IBD). In this study, ultrahigh-performance liquid chromatography equipped with quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) was used to analyze the untargeted lipidomics and compare plasma l...
2021-10-18 | MTBLS1183 | MetaboLights
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