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ProteomicsRegulation of hyperoxia-induced neonatal lung injury via posttranslational cysteine redox modifications
Lung tissue from normoxia- or hyperoxia-treated control or SCNN1B overexpression mice were processed with a redox proteomics workflow and analyzed by LC-MS/MS with TMT based quantification. Data was searched with MS-GF+ using PNNL's DMS Processing pipeline.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-08-18 | MSV000090157 | MassIVE
ProteomicsCharacterization of cytokine treatment on human pancreatic islets by top-down proteomics
Top-down proteomic data from 6 human islet donors; islets were treated with interferon gamma (IFN-gamma) and interleukin-1 beta (IL-1 beta). Time points include t=0 (control) and t=24 hours for each donor. Samples were reduced and alkylated, then analyzed by LC-MS/MS. Data was searched with TopPIC u...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-05-06 | MSV000097810 | MassIVE
ProteomicsA comprehensive urine proteome database generated from patients with various renal conditions and prostate cancer
A total of 45 urine samples from 5 prostate cancer (PC) patients, 10 renal transplant patients with proven acute rejection (AR), 10 renal transplant patients with stable graft (STA), 10 non-specific proteinuria patients (NS), and 10 healthy individuals (HI), were utilized for global urine proteome p...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-11-19 | MSV000086484 | MassIVE
ProteomicsRat Bronchoalveolar Lavage Proteome Changes Following E-cigarette Aerosol Exposures
Label free quantitative proteomics of bronchoalveolar lavage (BAL) fluid collected from rats exposed to e-cigarette aerosols (humidified air control, PG/VG, PG/VG + Nicotine, or PG/VG + Nicotine + Vanillin)
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2023-01-06 | MSV000091015 | MassIVE
ProteomicsMass spectrometry-based direct detection of multiple types of protein thiol modifications in pancreatic beta cells under endoplasmic reticulum stress
A 2D-LC-MS/MS strategy coupled with TMT-10 labeling was applied to mouse pancreatic beta cells (hetaTC-6) induced with ER stress by Thapsigargin to study the global proteome and protein cysteine PTM changes under ER stress. Samples were digested with trypsin, labeled with 10-plex TMT, then analyzed ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-05-29 | MSV000087543 | MassIVE
ProteomicsDefining the dynamic regulation of O-GlcNAc proteome in the mouse cortex -- The O-GlcNAcylation of synaptic and trafficking proteins related to neurodegenerative diseases
Mice were i.p. injected Thiamet G (TG) or saline, and mouse brain cortex tissues were analyzed for O-GlcNAc by LC-MS/MS with TMT based quantification. Data was searched with MS-GF+ using PNNL's DMS processing pipeline.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000088053 | MassIVE
Proteomics2H-Thiopyran-2-Thione Sulfine, a Compound For Converting H2S to HSOH/H2S2 and Increasing Intracellular Sulfane Sulfur Levels
Reactive sulfane sulfur species such as persulfides (RSSH) and H2S2 are important redox regulators and closely linked to H2S signaling. However, the study of these species is still challenging due to their instability, high reactivity, and the lack of suitable donors to produce these species. Herein...
ORGANISM(S): Oryctolagus Cuniculus (ncbitaxon:9986) 
2024-02-07 | MSV000094034 | MassIVE
ProteomicsH_UrinaryProt_Ctrl
Human urinary proteins, healthy control
ORGANISM(S): Homo Sapiens (human) 
2010-12-31 | PAe004097 | PeptideAtlas
ProteomicsHepatic SerpinA1 Improves Energy and Glucose Metabolism through Regulation of Preadipocyte Proliferation and UCP1 Expression
Fat tissue inducible specific IGF1R and IR (insulin receptor) KO mouse model to investigate the effect of insulin resistance on mature adipocytes. Mouse serum proteomics performed using TMT-10 analyses. Data was searched with MS-GF+ using PNNL's DMS Processing pipeline.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-11-21 | MSV000093454 | MassIVE
ProteomicsDefective insulin receptor signaling in hPSCs skews pluripotency and negatively perturbs neural differentiation
Proteomics and phosphoproteomics analyses of two human pluripotent stem cell (hPSC) lines with stable insulin receptor knock down. 6-plex TMT-based strategy was applied to compare control versus insulin receptor (IR) knockdown (n=3 replicates for each condition) for each cell lines (CHB8 and H9). D...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-04-16 | MSV000085298 | MassIVE
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