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MetabolomicsTriptolide clears Staphylococcus aureus infection by targeting XIAP to induce host apoptosis while preserving gut microbiota homeostasis

Background: Staphylococcus aureus (SA) remains a global health threat due to its increasing drug resistance and intracellular persistence, which compromise the efficacy of conventional antibiotics. Host-directed therapy (HDT) has emerged as a promising alternative by modulating host...

2026-02-25 | MTBLS13930 | MetaboLights
ProteomicsIdentification of regulators of polyploidization presents therapeutic targetsfor treatment of AMKL
Wen Q, Goldenson B, Silver SJ, Schenone M, Dancik V, Huang Z, Wang LZ, Lewis TA, An WF, Li X, Bray MA, Thiollier C, Diebold L, Gilles L, Vokes MS, Moore CB, Bliss-Moreau M, Verplank L, Tolliday NJ, Mishra R, Vemula S, Shi J, Wei L, Kapur R, Lopez CK, Gerby B, Ballerini P, Pflumio F, Gilliland DG, Go...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-01-27 | MSV000078536 | MassIVE
UnknownTRIM27 elicits protective immunity against tuberculosis by activating TFEB-mediated autophagy flux.
Not available
S-EPMC11210901 | biostudies-literature
TranscriptomicsTranscription profiling by array of the effect of SAH on brain cells in white matter region of mice
Using the SAH model to conduct experiments, set 5 groups of experimental groups and 5 groups of control groups. Studying the effects on the white matter cells of normal mice and the mice with SAH
ORGANISM(S): Mus musculus 
2019-10-10 | E-MTAB-8407 | biostudies-arrayexpress
UnknownThermally Reduced Graphene Oxide Membranes Revealed Selective Adsorption of Gold Ions from Mixed Ionic Solutions.
Not available
S-EPMC10418702 | biostudies-literature
UnknownSGLT-2 as a potential target in pancreatic cancer: the preliminary clue from The Cancer Genome Atlas data.
Not available
S-EPMC9660074 | biostudies-literature
UnknownA retrospective study for prognostic significance of type II diabetes mellitus and hemoglobin A1c levels in non-small cell lung cancer patients treated with pembrolizumab.
Not available
S-EPMC9459606 | biostudies-literature
ProteomicsTriptolide clears Staphylococcus aureus infection by targeting XIAP to induce host apoptosis while preserving gut microbiota homeostasis [Mouse lung macrophages]
Staphylococcus aureus (SA) remains a global health threat due to its increasing drug resistance and intracellular persistence, which compromise the efficacy of conventional antibiotics. Host-directed therapy (HDT) has emerged as a promising alternative by modulating host immunity. With the multi-tar...
ORGANISM(S): Mus musculus (Mouse) Staphylococcus aureus 
2026-05-18 | PXD074740 | Pride
Triptolide Microbiota homeostasis Host-directed therapy Methicillin-resistant staphylococcus aureus Apoptosis Xiap Staphylococcus aureus 
ProteomicsTriptolide clears Staphylococcus aureus infection by targeting XIAP to induce host apoptosis while preserving gut microbiota homeostasis [iBDMDs]
Staphylococcus aureus (SA) remains a global health threat due to its increasing drug resistance and intracellular persistence, which compromise the efficacy of conventional antibiotics. Host-directed therapy (HDT) has emerged as a promising alternative by modulating host immunity. With the multi-tar...
ORGANISM(S): Mus musculus (Mouse) Staphylococcus aureus 
2026-05-18 | PXD074476 | Pride
Triptolide Microbiota homeostasis Host-directed therapy Methicillin-resistant staphylococcus aureus Apoptosis Xiap Staphylococcus aureus 
UnknownPembrolizumab monotherapy or combination therapy for bone metastases in advanced non-small cell lung cancer: a real-world retrospective study.
Not available
S-EPMC8825649 | biostudies-literature
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