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Deciphering the regulatory network for human naïve and primed pluripotency is of fundamental theoretical and applicable significance. Here, by combining quantitative proteomics, phosphoproteomics and acetylproteomics analyses, we revealed RNA processing and translation as the most differentially-reg...
ORGANISM(S): Homo sapiens (Human) 
2021-12-10 | PXD030230 | Pride
Abstract Introduction: Type 1 diabetes (T1D) is a serious autoimmune disease with high morbidity and mortality. Early diagnosis and treatment remain unsatisfactory. Circulating exosomes containing T1D biomarkers have gained interest, but progress is limited. Objectives: This study investigates mole...
ORGANISM(S): Homo Sapiens 
2023-06-20 | PXD043146 |

Naïve human embryonic stem cells (hESCs) that resemble the pre-implantation epiblasts are fueled by a combination of aerobic glycolysis and oxidative phosphorylation, but their mitochondrial regulators are poorly understood. Here we report that, proline dehydrogenase (PRODH), a mitochondria-local...

2024-02-12 | MTBLS7832 | MetaboLights
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