Sort   by:  
 Page size 
ProteomicsQuantitative Chemical Proteomics Profiling of de novo Proteins Synthesis during Starvation-Mediated Autophagy
Autophagy is an intracellular degradation mechanism in response to nutrient starvation. Via autophagy, some non-essential cellular constituents are degraded in a lysosome-dependent manner to generate biomolecules that can be utilized for maintaining the metabolic homeostasis. Although it is known th...
ORGANISM(S): Homo sapiens (Human) 
2016-10-18 | PXD003546 | Pride
Autophagy Boncat Proteomics Aha De novo protein synthesis Itraq 
ProteomicsA Quantitative Chemical Proteomics Approach to Profile the Specific Cellular Targets of Andrographolide, a Promising Anticancer Agent that Suppresses Tumor Metastasis
Drug target identification is a critical step towards the understanding of the mechanism of action of a drug, which will help to improve the current therapeutic regime and to expand the drug’s therapeutic potential. However, current in vitro affinity chromatography-based and in vivo activity- based ...
ORGANISM(S): Homo sapiens (Human) 
2019-11-28 | PXD000588 | Pride
Chemical biology  drug targets*  itraq  mass spectrometry Molecular probes*   antitumor agents  metastasis 
ProteomicsHeme-activated Promiscuous Targeting of Artemisinin in Plasmodium falciparum
Plasmodium falciparum, the most pathogenic human malaria parasite, infects millions of human beings and causes a serious public health threat. Currently, the most potent anti-malarial drugs are artemisinin and its derivatives1,2. Artemisinin is a sesquiterpene lactone with an endoperoxide bridge3. T...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2015-12-17 | PXD002611 | Pride
Mechanism of action Target Artemisinin Chemical proteomics 
GenomicsGenome-wide Analyses of Transcription Factor GATA3-Mediated Gene Regulation in Distinct T Cell Types
We report genome-wide characterization of GATA3 binding sites in eleven well-defined developmental and effector cell types of the T lymphocyte lineage. By utilizing a conditional allele of GATA3, we investigated the impact of GATA3 expression on the mRNA expression patterns in several of these cell...
ORGANISM(S): Mus musculus 
2011-08-26 | E-GEOD-20898 | biostudies-arrayexpress
Sort   by:  
 Page size