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UnknownDifferential Detergent Fractionation of Membrane Protein From Small Samples of Hepatocytes and Liver Tissue for Quantitative Proteomic Analysis of Drug Metabolizing Enzymes and Transporters.
Not available
S-EPMC7750260 | biostudies-literature
ProteomicsImpact of Variation in CYP3A and CYP2C8 on Tucatinib Metabolic Clearance in Human Liver Microsomes
Tucatinib is a tyrosine kinase inhibitor (TKI) indicated for HER2 positive breast cancer. It is metabolized primarily by cytochrome P450 (CYP) 2C8 and CYP3A. Given the interindividual variability in the pharmacokinetics of some TKIs, this study explored how variability in CYP2C8 and CYP3A activities...
ORGANISM(S): Homo sapiens (Human) 
2025-04-17 | PXD057282 | Pride
Quantitative proteomics M-class acquity Kinase inhibitor Triple quadrupole 7500 
UnknownAltered Expression of Small Intestinal Drug Transporters and Hepatic Metabolic Enzymes in a Mouse Model of Familial Alzheimer's Disease.
Not available
S-EPMC6440746 | biostudies-literature
UnknownValidation of a P-Glycoprotein (P-gp) Humanized Mouse Model by Integrating Selective Absolute Quantification of Human MDR1, Mouse Mdr1a and Mdr1b Protein Expressions with In Vivo Functional Analysis for Blood-Brain Barrier Transport.
Not available
S-EPMC4416786 | biostudies-literature
ProteomicsDevelopment of an In Vitro Metabolic Dysfunction-Associated Steatohepatitis Model to Investigate Altered Drug Metabolizing Enzymes, Transport Proteins, and Hepatobiliary Disposition
Metabolic dysfunction-associated steatotic liver disease (MASLD) is estimated to affect approximately 30% of adults worldwide. The progressive form of MASLD, namely metabolic-dysfunction steatohepatitis (MASH), is a leading cause of chronic liver disease. MASH is marked by hepatocellular fat accumul...
ORGANISM(S): Homo sapiens (Human) 
2025-12-12 | PXD071083 | Pride
Human Lc-msms Schh Mash 
UnknownEndogenous Coproporphyrin I and III are Altered in Multidrug Resistance-Associated Protein 2-Deficient (TR-) Rats.
Not available
S-EPMC7767637 | biostudies-literature
UnknownImpact of pregnancy related hormones on drug metabolizing enzyme and transport protein concentrations in human hepatocytes.
Not available
S-EPMC9532936 | biostudies-literature
ProteomicsQuantitative tandem affinity purification, an effective tool to investigate protein complex composition in plant hormone signaling: strigolactones in the spotlight
Phytohormones tightly regulate plant growth by integrating changing environmental and developmental cues. Although the key players have been identified in many plant hormonal pathways, the molecular mechanisms and mode of action of perception and signaling remain incompletely resolved. Characterizat...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2018-04-26 | PXD009083 | Pride
Qtap Plant hormone signaling Strigolactones Smxl7 
UnknownDevelopment of an in vitro metabolic dysfunction-associated steatohepatitis model to investigate altered drug metabolizing enzymes, transport proteins, and hepatobiliary disposition.
Not available
S-EPMC12832903 | biostudies-literature
ProteomicsDigestion time course of human liver plasma membrane
The selection of signature peptides is critical for reliable peptide quantification. The purpose of this study was to comprehensively assess the digestion efficiency and stability of tryptic peptides and to identify optimal signature peptides for human hepatic transporters and membrane marker protei...
ORGANISM(S): Homo Sapiens (human) 
2022-10-12 | PXD034402 | JPOST Repository
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