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ProteomicsAuranofin targets UBA1 and enhances UBA1 activity by facilitating ubiquitin trans-thioesterificlation to E2 ubiquitin-conjugating enzymes
UBA1 is the primary E1 ubiquitin-activating enzyme, regulating stability and function of numerous proteins via initiating their ubiquitination. Decreased or insufficient ubiquitination can cause or drive aging and many deadly diseases. Therefore, a small-molecule UBA1 activity enhancer could have br...
ORGANISM(S): Homo sapiens (Human) 
2023-07-10 | PXD042558 | Pride
Ubiquitination Uba1 Auranofin 
ProteomicsA small molecule VDAC ligand inhibits ERAD and induces selective cancer cell death via disruption of calcium homeostasis
Endoplasmic reticulum-associated degradation (ERAD) is a critical protein quality control mechanism that also regulates lipid metabolism and calcium homeostasis. Dysregulation of ERAD and unfolded protein response underlies diseases including cancer, neurodegenerative disorders, and metabolic syndro...
ORGANISM(S): Homo sapiens (Human) 
2026-01-20 | PXD071546 | Pride
Erad Proteomics Ingel digestion Er-phagy Vdac 
UnknownEfficacy and safety of histone deacetylase inhibitors in peripheral T-cell lymphoma: a systematic review and meta-analysis on prospective clinical trials.
Not available
S-EPMC10293743 | biostudies-literature
UnknownTargeting SRSF1 improves cancer immunotherapy by dually acting on CD8<sup>+</sup>T and tumor cells.
Not available
S-EPMC11751439 | biostudies-literature
UnknownPerformance of the London Atlas, Willems, and a new quick method for dental age estimation in Chinese Uyghur children.
Not available
S-EPMC9773604 | biostudies-literature
UnknownTargeting HMGB2 acts as dual immunomodulator by bolstering CD8<sup>+</sup> T cell function and inhibiting tumor growth in hepatocellular carcinoma.
Not available
S-EPMC12047442 | biostudies-literature
UnknownCommunal breeding by women is associated with lower investment from husbands.
Not available
S-EPMC10426074 | biostudies-literature
UnknownEffects of consumer-oriented health information technologies in diabetes management over time: a systematic review and meta-analysis of randomized controlled trials.
Not available
S-EPMC7651962 | biostudies-literature
UnknownPCK1 activates oncogenic autophagy via down-regulation Serine phosphorylation of UBAP2L and antagonizes colorectal cancer growth.
Not available
S-EPMC10105959 | biostudies-literature
UnknownDiscovery of a novel IL-15 based protein with improved developability and efficacy for cancer immunotherapy.
Not available
S-EPMC5955975 | biostudies-literature
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