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Comprehensive landscape of active deubiquitinating enzymes profiled by advanced chemoproteomics
Chemoproteomics identitied coatomer subunit zeta-1 as the anti-EV71 target of a marinopyrrole A derivate
ORGANISM(S): Homo Sapiens 
The etiological agents of PCM belong to the Paracoccidioides genus, which is restricted to Latin America. The infection is acquired through inhalation of conidia that primarily lodge in the lungs and may disseminate to other organs/tissues. Treatment of PCM is commonly achieved via administration of...
ORGANISM(S): Paracoccidioides brasiliensis (strain Pb18) 
2018-02-07 | PXD007680 | Pride
Enzymes that bind and process ubiquitin, a small 76 amino acid protein, have been recognized as pharmacological targets in oncology, immunological disorders and neurodegeneration. Mass spectrometry technology has now reached the capacity to cover the proteome with enough depth to interrogate entire ...
ORGANISM(S): Homo sapiens 
2019-08-31 | GSE134954 | GEO
Here we use competitive chemoproteomics pulldowns followed by label-free quantitative LC-MS/MS to assess target engagement and selectivity profiles of UNC6934 and UNC7145, a chemical probe targeting the PWWP1 domain of NSD2 and its negative control counterpart, respectively. To this end, we used a b...
ORGANISM(S): Homo sapiens (Human) 
2021-08-06 | PXD017641 | Pride
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