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MetabolomicsInteraction of Genetic Variants Activates Latent Metabolic Pathways in Yeast

Genetic interactions are fundamental to the architecture of complex traits, yet the molecular mechanisms by which variant combinations influence cellular pathways remain poorly understood. Here, we answer the question of whether interactions between genetic variants can activate unique pathways a...

2025-07-22 | MTBLS12761 | MetaboLights
MetabolomicsBiological Characteristics of SARS-CoV-2 Resistant Populations: A Cohort Comparison Study through Integrated Gut Microbiota Sequencing, Metabolomics and Proteomics

Objective: Most research reports on COVID-19 infections have focused on the correlation between the severity of the disease symptoms and immune deficits, while the mechanisms affecting the susceptibility to SARS-CoV-2 remain largely unknown. The study aimed to comprehensively analyze the differen...

2025-06-28 | MTBLS12654 | MetaboLights
UnknownUnbiased RNA-protein interaction screen by quantitative proteomics.
Not available
S-EPMC2697111 | biostudies-literature
UnknownQuantitative interaction proteomics of neurodegenerative disease proteins.
Not available
S-EPMC9014711 | biostudies-literature
GenomicsQuantitative Proteomics Identifies Profilin-1 as a Pseudouridine-Binding Protein
Quantitative Proteomics Identifies Profilin-1 as a Pseudouridine-Binding Protein
PRJNA1062713 | ENA
UnknownQuantitative proteomics combined with BAC TransgeneOmics reveals in vivo protein interactions.
Not available
S-EPMC2872919 | biostudies-literature
OtherQuantitative interaction proteomics of neurodegenerative disease proteins.
Data from ProteomeXchange, PXD ID: PXD001942. File: 20130829_Orbi6_FaHo_SA_NN_SWEvsEV_Rep3_01.mzml. Published as part of Cell Rep. 2015 May 19;11(7):1134-46 . From the Abstract: {{i}} Several proteins have been linked to neurodegenerative disorders (NDDs), but their molecular function is not comple...
ORGANISM(S): Homo_sapiens_viruses, Human_female 
GPM32320018141 | GPMDB
Resource Reanalysis 
ProteomicsQuantitative interaction proteomics of neurodegenerative disease proteins
Several proteins have been linked to neurodegenerative disorders (NDDs), but their molecular function is not completely understood. Here, we used quantitative interaction proteomics to identify binding partners of Amyloid beta precursor protein (APP) and Presenilin-1 (PSEN1) for Alzheimer’s diseas...
ORGANISM(S): Homo sapiens (Human) 
2015-09-22 | PXD001942 | Pride
Neurodegeneration Qap-ms 
UnknownAnnotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics.
Not available
S-EPMC4117722 | biostudies-literature
ProteomicsRegulation of the HTRA2 protease activity by PDZ domain-binding peptide ligands and the influence on HTRA2-specific protein interaction networks in retinal tissues
For the identification of HTRA2-specific protein interaction partners in retinal tissues of the house swine (Sus scrofa), we performed co-immunoprecipitation experiments with recombinant 6His-tag HTRA2 followed by quantitative LC-MS-based proteomics (see Fig. 2A and File S1). In brief, 2 µg recombin...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2021-10-11 | PXD024442 | Pride
Htra2  neuroprotection  retina  interaction partners  co-immunoprecipitation  mass spectrometry 
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