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ProteomicsA Quantitative Proteome Map of the Human Body
In this study, we quantified the relative protein levels from 12,627 genes across 32 normal human tissue types prepared by the GTEx project. Known and new tissue specific or enriched proteins were identified and compared to transcriptome data. Many ubiquitous transcripts are found to encode highly t...
ORGANISM(S): Homo sapiens (Human) 
2020-11-16 | PXD016999 | Pride
Quantitative proteomics of 32 normal human tissues 
ProteomicsA Quantitative Proteome Map of the Human Body
In this study, we quantified the relative protein levels from 12,627 genes across 32 normal human tissue types prepared by the GTEx project. Known and new tissue specific or enriched proteins were identified and compared to transcriptome data. Many ubiquitous transcripts are found to encode highly t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-10-30 | MSV000086387 | MassIVE
ProteomicsQuantitative LC-MS/MS Proteomics of human small intestine
The objective was to determine the expression of a wide range proteins pertinent to metabolism and disposition of chemicals and nutrients in the intestinal epithelium. Ileum and jejunum biopsy specimens were obtained from 16 patients undergoing gastrointestinal elective surgery. Mucosal fractions we...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020987 | Pride
Human Jejunum Small intestine Gut Quantitative proteomics Ileum Lc-ms/ms 
MetabolomicsComprehensive systems biology analysis of a seven-month cigarette smoke inhalation study in C57BL/6 mice
Smoking of combustible cigarettes has a major impact on human health. Using a systems toxicology approach in a model of chronic obstructive pulmonary disease (C57BL/6 mice), we assessed the health consequences in mice of smoke derived from a prototype modified risk tobacco product (pMRTP) as compare...
2015-11-19 | MTBLS143 | MetaboLights
ProteomicsA large-scale assay library for targeted protein quantification in renal cell carcinoma tissues
Generation of a new library of targeted mass spectrometry assays for accurate protein quantification in malignant and normal kidney tissue. Aliquots of primary tumor tissue lysates from 86 patients with initially localized renal cell carcinoma (RCC), 75 patients with metastatic RCC treated with suni...
ORGANISM(S): Homo sapiens (Human) 
2022-01-03 | PXD028411 | Pride
Data independent acquisition Targeted proteomics Assay library Spectral library Renal cancer Selected reaction monitoring 
ProteomicsLoss of HIF1A From Pancreatic Cancer Cells Increases Expression of PPP1R1B and Degradation of p53 to Promote Invasion and Metastasis
Here we utilized a mouse model of PDAC and human pancreatic cancer cell lines to investigate the role of HIF1alpha in pancreatic cancer. Contrary to the conventional notion that HIF1alpha plays a tumor promoting role in several cancers, our findings indicate a tumor suppressive role of HIF1alpha in ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-08-21 | MSV000084223 | MassIVE
ProteomicsQuantitative proteomic analysis of serum-purified exosomes reveals putative pre-eclampsia associated biomarkers
The high incidence of pre-eclampsia, affecting 5-10% of pregnancies, makes it a major health problem. Early detection of pre-eclampsia, before the appearance of the first clinical symptoms, is therefore an urgent need, since it would allow the early intervention. Identification of plasma/serum bioma...
ORGANISM(S): Homo sapiens (Human) 
2022-02-21 | PXD025308 | Pride
Pre-eclampsia Exosome Proteomics Pregnancy Mass spectrometry Plasma Serum Biomarkers Cohort studies 
ProteomicsMolecular characterization of esophageal squamous cell carcinoma using quantitative proteomics
Esophageal squamous cell carcinoma (ESCC) is a heterogeneous cancer associated with high mortality rate. In India, it is the 6th most common cause of cancer-related mortality. In this study, we employed high-resolution mass spectrometry-based quantitative proteomics to characterize differential prot...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD036238 | Pride
Quantitative proteomics Cell cycle regulation Syvn1 Esophageal squamous cell carcinoma Er stress 
ProteomicsCommon, Unique and Systemic Signatures in gender-dependent hepatic tumorigenesis: a TMT-based quantitative proteomic analysis
Hepatocellular carcinoma (HCC) is the most common liver cancer and a highly malignant tumor. The frequent activation of Ras signaling pathway and the male prevalence are the distinct characteristics of HCC though the underlying mechanisms remain elucidated. By exploring a mouse model of HCC induced ...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD012410 | Pride
Hepatocellular carcinoma  gender disparity  ras oncogene  proteomics  tandem-mass-tag (tmt) 
ProteomicsConvergence of KSHV Reactivation with EBV latency and cellular growth mediated by the Notch signaling pathway in co-infected cells.
Kaposi’s sarcoma-associated herpesvirus (KSHV) is the etiologic agent of primary effusion lymphoma (PEL). All PEL cell lines are infected with KSHV, and 70% are co-infected with Epstein-Barr Virus (EBV). KSHV reactivation from latency requires promoter-specific transactivation by the KSHV Rta prote...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-GEOD-21375 | biostudies-arrayexpress
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