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TranscriptomicsToxin-antitoxin of Rickettsia determines fatal addiction of the host cells
Rickettsia spp. can cause mild to severe human disease. These intracellular bacteria are associated with arthropods, nematodes and trematodes, and usually, are efficiently transmitted transovarially to the progeny of the invertebrate host. We recently demonstrated foreign gene acquisition by lateral...
ORGANISM(S): Homo sapiens 
2012-05-23 | E-GEOD-22072 | biostudies-arrayexpress
UnknownDestroyed bladders: Characterization of progressive inflammatory cystitis.
Not available
S-EPMC11542153 | biostudies-literature
TranscriptomicsEffect of maternal treatment on gene expression differences in Bacillus thuringiensis infected pooled larvae
This study examines gene expression differences between infected larvae from different maternal infection backgrounds to try to understand the immunological basis of invertebrate immune priming. Female Tribolium castaneum beetles were either jabbed with sterile saline, heat killed Bt, or left naïve...
ORGANISM(S): Tribolium castaneum 
2016-06-01 | E-GEOD-44912 | biostudies-arrayexpress
TranscriptomicsLiver Transcriptomics data from mouse model with Features of Post-traumatic Stress Disorder
We have used a social defeat (SD) mouse model of post-traumatic stress disorder (PTSD) that is based on a brief exposure of a mouse to the aggressor mice for either 5 d or 10 d stress periods. Mice simulating aspects of posttraumatic stress disorder exhibit behavioral changes, body weight gain, incr...
ORGANISM(S): Mus musculus 
2014-06-07 | E-GEOD-58275 | biostudies-arrayexpress
TranscriptomicsMolecular subtypes in pancreatic adenocarcinoma [tumors, normal and pancreatitis]
The goal of the study was to examine the transcriptional profile of pancreatic tumors to identify molecular subtypes in order to develop validated clinically useful gene expression signature with the potential to guide therapy decision. Tissue was obtained by snap freezing in liquid nitrogen as soo...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-77858 | biostudies-arrayexpress
TranscriptomicsMolecular subtypes in pancreatic adenocarcinoma [pancreatic cancer cell lines]
The goal of the study was to examine the transcriptional profile of pancreatic cancer cell lines and assess if the molecular subtypes observed in tumor samples were represented in existing cell line models. Cell line models allow us to investigate if the molecular subtype observed in tumor have uni...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-77850 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation and RNA-seq analysis in purified quiescent yeast cells to identify the genomic RNA polymerase II and histone H3 methylation occupancy profiles and the transcriptome
A defining characteristic of quiescent cells is their low level of gene activity compared to growing cells. Using a yeast model for cellular quiescence, we compared the genome-wide profiles of multiple histone modifications between growing and quiescent cells, and correlated these profiles with the...
ORGANISM(S): Saccharomyces cerevisiae 
2015-09-09 | E-GEOD-72802 | biostudies-arrayexpress
TranscriptomicsThe ability of VSL#3 to restore the age-related deficit in LTP is associated with changes in brain genes expression
A deficit in synaptic plasticity is one of the many changes that occurs with age. Specifically the archetypal model of plasticity, long-term potentiation (LTP), is reduced in hippocampus of middle-aged and aged animals. Several factors are likely to contribute to this deficit including morphologic...
ORGANISM(S): Rattus norvegicus 
2014-04-02 | E-GEOD-51381 | biostudies-arrayexpress
TranscriptomicsA comprehensive analysis of blood host responses to Yersinia Pestis infection Temporal Progression of Pneumonic Plague in Blood of Nonhuman Primate: A Transcriptomic Analysis
transcriptomic analyses showed there was a very rapid proliferation of Y. pestis in assault on African green monkeys. The bacterial loads were enumerated in the blood at delayed time points supporting earlier observations (Layton et al., 2011). Interpretation of transcriptomic changes reveals that...
ORGANISM(S): Chlorocebus aethiops 
2016-01-14 | E-GEOD-63560 | biostudies-arrayexpress
TranscriptomicsPostnatal glucocorticoids suppress myelination in a dose-dependent manner by genomic mechanism
Objective: Postnatal glucocorticoids (GCs) are widely used in the prevention of chronic lung disease in premature infants. However, their use is associated with neurodevelopmental delay and cerebral palsy. We hypothesized that postnatal dexamethasone or betamethasone in high-dose, but not low-dose, ...
ORGANISM(S): Oryctolagus cuniculus 
2013-02-27 | E-GEOD-44610 | biostudies-arrayexpress
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