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TranscriptomicsCultured chicken embryonic hepatocytes (CEH) exposed to linear PFOS (L-PFOS) or technical-grade PFOS (T-PFOS)
Recently it was discovered that the perfluorooctane sulfonate (PFOS) detected in wildlife, such as fish-eating birds, had a greater proportion of linear PFOS (L-PFOS) than the manufactured technical product (T-PFOS), which contains linear and branched isomers. This suggests toxicological studies bas...
ORGANISM(S): Gallus gallus 
2011-10-28 | E-GEOD-33291 | biostudies-arrayexpress
TranscriptomicsMyc-regulated gene expression in human fibroblasts
Myc regulates many gene expression during cell growth, development, or other many cellular events. C-Myc is a well known molecule which expression increase in many cancers. Overexpression of c-Myc causes cell transformation, apoptosis, etc. There are several Myc family genes in human, mouse, or othe...
ORGANISM(S): Homo sapiens 
2010-07-26 | E-GEOD-22654 | biostudies-arrayexpress
ProteomicsCRISPR-Cas9 genetic screen leads to the discovery of L-Moses, a KAT2B inhibitor that attenuates Tunicamycin-mediated neurodegeneration
Accumulation of aggregated and misfolded proteins, leading to endoplasmic reticulum stress and activation of the unfolded protein response, is a hallmark of several neurodegenerative disorders, including Alzheimer’s and Parkinson’s disease. Genetic screens are powerful tools that are proving invalua...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD038395 | Pride
Cortical neurons Kat2b L-moses Endoplasmic reticulum (er) stress Acetylome 
TranscriptomicsTranscriptome Comparison of Cabernet Sauvignon Grape Berries from Two Regions with Distinct Climate
To obtain an interpretation from the view of transcriptome on distinct metabolite accumulation between ecologically different regions in China, next-generation sequencing technology was performed on E-L 31, 35 and 38 stages of Cabernet Sauvignon grape berries from Changli (CL, eastern) and Gaotai (G...
ORGANISM(S): Vitis vinifera 
2014-11-21 | E-GEOD-63512 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of zebrafish livers following exposure to 17 alpha-ethynylestradiol (EE2) at 0, 15, 40, or 100 ng/L
Genomic, proteomic, and metabolomic technologies continue to receive increasing interest from environmental toxicologists. This interest is due to the great potential of these technologies to identify detailed modes of action and to provide assistance in the evaluation of a contaminant?s risk to aq...
ORGANISM(S): Danio rerio 
2007-02-24 | E-TABM-105 | biostudies-arrayexpress
MetabolomicsMetabolomic approaches to dissect dysregulated metabolism in the progression of pre-diabetes to T2DM

Most of pre-diabetes were eventually progress to diabetes, thereby profiling of prediabetic metabolic disorders may be an effective targeted preventive measure. We aimed to elucidate internal motivation of the progression of pre-diabetes to type 2 diabetes mellitus (T2DM) from a metabolic perspec...

2024-04-29 | MTBLS8644 | MetaboLights
TranscriptomicsEthylene and 1-MCP differentially regulate gene expression during onion (Allium cepa L.) sprout suppression
Onion is regarded as non-climacteric. In onion, ethylene can suppress sprouting however, the ethylene binding inhibitor, 1-MCP can also suppress sprout growth although it is unknown how ethylene and 1-MCP elicit the same response. In this study, onion bulbs were treated with 10 μL L-1 ethylene or 1...
ORGANISM(S): Allium cepa 
2011-06-29 | E-GEOD-27132 | biostudies-arrayexpress
TranscriptomicsPost-epidemic eosinophilia myalgia syndrome associated with L-Tryptophan
Eosinophilia–myalgia syndrome (EMS) is characterized by subacute onset of myalgias and peripheral eosinophilia, followed by chronic neuropathy and skin induration. The EMS epidemic in 1989 was linked to L-tryptophan consumption originating from a single source. Following the Food and Drug Administra...
ORGANISM(S): Homo sapiens 
2012-01-28 | E-GEOD-26934 | biostudies-arrayexpress
GenomicsMicroarray analysis of OVSAHO and KURAMOCHI cells incubated with simvasatin or L-778123
Microarray analysis of OVSAHO and KURAMOCHI cells incubated with simvasatin or L-778123
PRJNA760926 | ENA
UnknownThe Evaluation of Roasted Lentils (L. culinaris L.) Quick Meals as An Alternative to Meat Dishes.
Not available
S-EPMC10778251 | biostudies-literature
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