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ProteomicsCRISPR-Cas9 genetic screen leads to the discovery of L-Moses, a KAT2B inhibitor that attenuates Tunicamycin-mediated neurodegeneration
Accumulation of aggregated and misfolded proteins, leading to endoplasmic reticulum stress and activation of the unfolded protein response, is a hallmark of several neurodegenerative disorders, including Alzheimer’s and Parkinson’s disease. Genetic screens are powerful tools that are proving invalua...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD038395 | Pride
Cortical neurons Kat2b L-moses Endoplasmic reticulum (er) stress Acetylome 
UnknownCRISPR-Cas9 genetic screen leads to the discovery of L-Moses, a KAT2B inhibitor that attenuates Tunicamycin-mediated neuronal cell death.
Not available
S-EPMC9998435 | biostudies-literature
UnknownEvaluating the GCN5b bromodomain as a novel therapeutic target against the parasite Toxoplasma gondii.
Not available
S-EPMC7483680 | biostudies-literature
UnknownDiscovery of a PCAF Bromodomain Chemical Probe.
Not available
S-EPMC5412877 | biostudies-literature
UnknownThe Accuracy of Diagnostic Methods for Diabetic Retinopathy: A Systematic Review and Meta-Analysis.
Not available
S-EPMC4849768 | biostudies-literature
UnknownSerum Activity of Liver Enzymes Is Associated With Higher Mortality in COVID-19: A Systematic Review and Meta-Analysis.
Not available
S-EPMC7387424 | biostudies-literature
ProteomicsComparative Proteomic Analysis of Porphyromonas gingivalis challenged Human Dental Pulp Stem Cells
Dental pulp stem cells (DPSCs) are increasingly recognised for their potential in regenerative medicine, particularly in oral and maxillofacial surgeries. However, the unique microbial environment of the oral cavity necessitates a better understanding of how bacterial challenges may affect DPSC func...
ORGANISM(S): Homo sapiens (Human) 
2025-11-21 | PXD064913 | Pride
Secretome proteomic analysis Regenerative therapy Dental pulp stem cells Dpsc-pathogen interactions Porphyromonas gingivalis infection 
UnknownGeospatially informed representation of spatial genomics data with SpatialFeatureExperiment.
Not available
S-EPMC11888365 | biostudies-literature
UnknownEthical conflict and moral distress in veterinary practice: A survey of North American veterinarians.
Not available
S-EPMC6271308 | biostudies-literature
UnknownThe endogenous zinc finger transcription factor, ZNF24, modulates the angiogenic potential of human microvascular endothelial cells.
Not available
S-EPMC4734806 | biostudies-literature
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