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TranscriptomicsGenetic architecture of murine skin inflammation and tumor susceptibility
Gene expression in self-renewing epithelial tissues is controlled by cis- and trans-activating regulatory factors that mediate responses to exogenous agents capable of causing tissue damage, infection, inflammation, or tumorigenesis. We used network construction methods to analyze the genetic archi...
ORGANISM(S): Mus musculus 
2008-12-31 | E-GEOD-12248 | biostudies-arrayexpress
TranscriptomicsProgressive genomic instability in the FVB/KrasLA2 mouse model of lung cancer
Alterations in DNA copy number contribute to the development and progression of cancers and are common in epithelial tumors. We have used array Comparative Genomic Hybridization (aCGH) to visualize DNA copy number alterations across the genomes of lung tumors in the KrasLA2 model of lung cancer. C...
ORGANISM(S): Mus musculus 
2011-11-22 | E-GEOD-29230 | biostudies-arrayexpress
TranscriptomicsThe 5p12 breast cancer susceptibility locus affects MRPS30 expression in estrogen-receptor positive tumors
Uninvolved tissue taken at the time of primary surgical resection of an adenocarcinoma. Uninvolved status determined by surgical margin and gross appearance, not pathology 35 biologically distinct samples, no replicates, no controls
ORGANISM(S): Homo sapiens 
2014-05-22 | E-GEOD-48067 | biostudies-arrayexpress
ProteomicsAbnormalities of mitochondrial dynamics and bioenergetics in neuronal cells from CDKL5 deficiency disorder
CDKL5 deficiency disorder (CDD) is a rare neurodevelopmental disorder caused by pathogenic variants in the Cyclin-dependent kinase-like 5 (CDKL5) gene, resulting in dysfunctional CDKL5 protein. It predominantly affects females and causes seizures in the first few months of life, ultimately resulting...
ORGANISM(S): Homo sapiens (Human) 
2025-04-28 | PXD063372 | Pride
Cdkl5  cdkl5 deficiency disorder  induced pluripotent stem cell  mitochondria  oxidative phosphorylation  proteomics. 
TranscriptomicsExpression analysis of superior cervical ganglion from backcrossed TH-MYCN transgenic mice
Neuroblastoma susceptibility in TH-MYN mice is heavily influence by mouse strain background. We have combined linkage analysis of tumor susceptibility with expression QTL analysis of superior cervical ganglia (pure peripheral symptathetic nervous tissue) to identify genes underlying tumor formation...
ORGANISM(S): Mus musculus 
2015-01-30 | E-GEOD-59675 | biostudies-arrayexpress
UnknownProgressive genomic instability in the FVB/Kras(LA2) mouse model of lung cancer.
Not available
S-EPMC3196775 | biostudies-literature
TranscriptomicsThe genetics of splicing in neuroblastoma
Regulation of mRNA splicing is a critical and tightly regulated cellular function, underlying the majority of proteomic diversity in our genomes. While disruption of this process is common in disease, the basic genetic complexity of alternative splicing in vivo remains poorly understood. To delinea...
ORGANISM(S): Mus musculus 
2015-04-03 | E-GEOD-55248 | biostudies-arrayexpress
UnknownEfficacy and Safety of Prucalopride in Chronic Constipation: An Integrated Analysis of Six Randomized, Controlled Clinical Trials.
Not available
S-EPMC4943977 | biostudies-literature
UnknownThe Genomic and Epigenomic Landscape of Double-Negative Metastatic Prostate Cancer.
Not available
S-EPMC10425725 | biostudies-literature
UnknownA review of ferric citrate clinical studies, and the rationale and design of the Ferric Citrate and Chronic Kidney Disease in Children (FIT4KiD) trial.
Not available
S-EPMC9437144 | biostudies-literature
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