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TranscriptomicsMicroarray analysis of human umbilical vein endothelial cells (HUVECs) chronically irradiated with low dose-rate of ionizing radiation for one, three and six weeks.
To obtain more insight in the molecular effects of chronic low dose irradiation on endothelial cells, HUVEC were irradiated with low-dose rate irradiation (137Cs gamma source; 0, 1.4 and 4.1 mGy/h) for several weeks. At different time points (1, 3 and 6 weeks) cells were harvested for RNA extraction...
ORGANISM(S): Homo sapiens 
2018-02-28 | E-MTAB-6521 | biostudies-arrayexpress
TranscriptomicsRadiation exposure of human coronary artery endothelial cells - 1 day, 7 days, 14 days post-irradiation
In recent years there is a growing epidemiological indication of excess risk of cardiovascular disease at low doses of ionizing radiation without a clear-cut threshold. It is proposed that damage to the vascular endothelium is critical in radiation-related cardiovascular diseases. In order to identi...
ORGANISM(S): Homo sapiens 
2017-04-27 | E-MTAB-5054 | biostudies-arrayexpress
TranscriptomicsBulk RNA-seq of primary mouse neural progenitor cells derived from the embryonic neocortex or medial ganglionic eminence at different time points after exposure to ionizing radiation
Embryonic DNA damage, e.g. resulting from exposure to moderate and high doses of ionizing radiation, has important consequences on the normal neurodevelopment, often resulting in microcephaly that can be associated with seizures. The effects of prenatal radiation exposure have previously been invest...
ORGANISM(S): Mus musculus 
2025-10-01 | E-MTAB-14528 | biostudies-arrayexpress
TranscriptomicsRadiation exposure of mouse embryonic brain - 2 h, 24 h post-irradiation
The mammalian brain is especially sensitive to ionizing radiation during development, as shown by the increased occurrence of mental retardation and small head size in children who were in utero exposed to ionizing radiation after the atomic bombings of Hiroshima and Nagasaki. These effects of prena...
ORGANISM(S): Mus musculus 
2015-07-01 | E-MTAB-2720 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of peripheral blood mononuclear cells (PBMCs) 8 hours after exposure to 1 Gy of carbon or iron ions
Under certain circumstances, humans can be exposed to ionizing radiation from heavy ions. Examples are cancer patients undergoing particle therapy (e.g. carbon ions) or astronauts in deep Space missions (iron ions which contribute for a large fraction to the possible health effects of cosmic radiati...
ORGANISM(S): Homo sapiens 
2018-02-21 | E-MTAB-5761 | biostudies-arrayexpress
TranscriptomicsX-ray exposure of peripheral blood mononuclear cells
Peripheral blood mononuclear cells (PBMCs) were isolated using Histpaque-1077 (Sigma-Aldrich, Belgium) from 10 healthy donors (5 males, 5 females, aged 23-50). Isolated cells were resuspended at a density of 10^6 cells/ml and allowed to equilibrate to culture conditions at 37°C in a humidified 5% CO...
ORGANISM(S): Homo sapiens 
2016-01-14 | E-MTAB-3463 | biostudies-arrayexpress
TranscriptomicsMicroarray of heads of embryonic day (E) 9 mouse embryos, irradiated with 1-Gy X-rays at E7.5 compared to 0-Gy controls
Exposure to ionizing radiation around the time of neural tube closure results in a number of developmental defects, including neural tube defects (e.g. exencephaly, cleft palate) and eye defects (e.g. microphtalmos, anaphtalmos). These defects result from perturbed neural tube closure and developmen...
ORGANISM(S): Mus musculus 
2019-09-02 | E-MTAB-7532 | biostudies-arrayexpress
TranscriptomicsmRNA analysis of diaphragm and gastrocnimius of WT and Cox6a2 knockout mice
We used microarrays to compare gene expression across different murine tissues. 12 samples were analysed in this comparison, 3 biological replicates were used per tissue
ORGANISM(S): Mus musculus 
2013-03-01 | E-GEOD-41353 | biostudies-arrayexpress
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