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ProteomicsThe innate immunity kinase TAK1 phosphorylates Rab1 on a hotspot for post-translational modifications by host and pathogen
TGF-β Activated Kinase 1 (TAK1) is a critical signaling hub responsible for translating antigen binding signals to immune receptors for the activation of the AP-1 and NF-κB master transcriptional programs. Despite its importance, known substrates of TAK1 are limited to kinases of the MAPK and IKK fa...
ORGANISM(S): Homo sapiens (Human) 
2016-07-19 | PXD004213 | Pride
Kinase Covalent capture Kinase substrates Analog specific kinase 
ProteomicsA Rab1 interactome illuminates its dual role in autophagy and membrane trafficking
The small GTPase Rab1 is found in all eukaryotes and acts in both ER-to-Golgi transport and autophagy. Several Rab1 effectors and regulators have been identified, but the mechanism by which Rab1 orchestrates these distinct processes remains incompletely understood. We apply MitoID, a proximity bioti...
ORGANISM(S): Homo sapiens (Human) 
2025-12-18 | PXD065220 | Pride
Membrane trafficking Autophagy Rab1 Interactome 
ProteomicsA cryo-EM structure of metazoan TRAPPIII, the multisubunit complex that activates the GTPase Rab1
The TRAPP complexes are nucleotide exchange factors that have essential roles in membrane traffic and autophagy. TRAPPII activates Rab11, and TRAPPIII activates Rab1, with the two complexes sharing a core of small subunits that affect nucleotide exchange, but being distinguished by specific large su...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-06-03 | PXD025064 | Pride
Exchange factor / rab1 / autophagy / membrane traffic / golgi 
ProteomicsA Rab1 interactome illuminates its dual role in autophagy and membrane trafficking
The small GTPase Rab1 is found in all eukaryotes and acts in both ER-to-Golgi transport and autophagy. Several Rab1 effectors and regulators have been identified, but the mechanism by which Rab1 orchestrates these distinct processes remains incompletely understood. We apply MitoID, a proximity bioti...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-05 | PXD070863 | Pride
Crosslinking Sda 
ProteomicsRab1b-AMPylation by Legionella DrrA is allosterically activated by Rab1
Legionella pneumophila infect eukaryotic cells by forming a replicative organelle – the Legionella containing vacuole. During this process, the bacterial protein DrrA/SidM is secreted and manipulates the activity and posttranslational modification (PTM) states of the vesicular trafficking regulator ...
ORGANISM(S): Legionella pneumophila Homo sapiens (Human) 
2021-01-04 | PXD019043 | Pride
Crosslink Legionella Rab Drra 
UnknownRab1-AMPylation by Legionella DrrA is allosterically activated by Rab1.
Not available
S-EPMC7815794 | biostudies-literature
UnknownStructural basis of TRAPPIII-mediated Rab1 activation.
Not available
S-EPMC8204860 | biostudies-literature
UnknownAMPylation is critical for Rab1 localization to vacuoles containing Legionella pneumophila.
Not available
S-EPMC3950522 | biostudies-literature
UnknownLegionella pneumophila SidD is a deAMPylase that modifies Rab1.
Not available
S-EPMC3146296 | biostudies-literature
UnknownRegulation of the small GTPase Rab1 function by a bacterial glucosyltransferase.
Not available
S-EPMC6175885 | biostudies-literature
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