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GenomicsChIPseq of RNA Exosome components in BMEL cell lines invalidated or not for the expression of the three HP1 isoforms (CBX1, CBX3, CBX5)
Chromatin association of several nuclear RNA exosome components and cofactors in BMEL cells is dependent on the presence of HP1 proteins. TKO2 cells invalidated for the expression of the three HP1 isoforms (Cbx1-/-; Cbx3-/-; Cbx5-/-) are compared to Het32 cells (Cbx1+/+; Cbx3+/+; Cbx5+/-) expressing...
ORGANISM(S): Mus musculus 
2026-03-31 | E-MTAB-15196 | biostudies-arrayexpress
TranscriptomicsATACseq in BMEL cells invalidated or not for the expression of the three HP1 isoforms (CBX1, CBX3, CBX5)
Chromatin accessibility assay by ATACseq in BMEL cells. Three clones (TKO1, TKO2, TKO3) of BMEL TKO cells invalidated for the expression of the three HP1 isoforms (Cbx1-/-; Cbx3-/-; Cbx5-/-) were compared to three clones (Het1, Het32, Het35) of BMEL Het cells (Cbx1+/+; Cbx3+/+; Cbx5+/-) as controls.
ORGANISM(S): Mus musculus 
2026-03-31 | E-MTAB-15197 | biostudies-arrayexpress
TranscriptomicsRNAseq of BMEL cell lines invalidated or not for the expression of the three HP1 isoforms (CBX1, CBX3, CBX5)
Expression profiling by high throughput sequencing in Bi-potential Murine Embryonic Liver cells (BMEL cells). Three clones (TKO1, TKO2, TKO3) of BMEL TKO cells invalidated for the expression of the three HP1 isoforms (Cbx1-/-; Cbx3-/-; Cbx5-/-), compared to three clones (Het1, Het32, Het35) of BMEL ...
ORGANISM(S): Mus musculus 
2026-03-31 | E-MTAB-15194 | biostudies-arrayexpress
TranscriptomicsHP1, H3-K27me3, and H3-K9me3 Cut & Tag of Het (Cbx1+/+, Cbx3+/+, Cbx5+/-) and TKO (Cbx1-/-, Cbx3-/-, Cbx5-/-) bipotential mouse embryonic liver (BMEL) cells
Cut & Tag was used to localize the 3 mouse HP1 proteins (Cbx1,Cbx3,Cbx5) to the genome of BMEL (bipotential mouse embryonic liver) cells. Het BMEL cells are Cbx1+/+, Cbx3+/+, Cbx5+/- HP1-TKO (triple knock-out cells) are Cbx1-/-, Cbx3-/-, Cbx5-/-. The HP1_TKO cells were used to verify the specificity...
ORGANISM(S): Mus musculus 
2025-06-14 | E-MTAB-15189 | biostudies-arrayexpress
TranscriptomicsImpact of HP1gamma and HP1gamma S83 phosphorylation on the transcriptionnal effect of PMA stimulation of mouse fibroblasts
We have here followed the transcriptional effect of stimulation with the phorbol ester PMA in mouse fibroblasts from HP1gamma null mice recomplemented with either wild-type HP1gamma or an HP1g with an S83A mutation Spontaneously immortalized mouse embryonic fibroblasts from HP1gamma null mice were u...
ORGANISM(S): Mus musculus 
2014-11-01 | E-GEOD-60283 | biostudies-arrayexpress
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