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UnknownMeta-analysis of Immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations.

Background

In recent years, research has consistently proven the occurrence of genetic overlap across autoimmune diseases, which supports the existence of common pathogenic mechanisms in autoimmunity. The objective of this study was to further investigate this shared genetic component.

Me...

S-EPMC6302306 | biostudies-literature
ProteomicsIn-depth Serum Proteomics in Psoriasis reveals novel biomarkers for disease activity and response to Traditional Chinese Medicine
demonstrate the clinical utility of our in-depth serum proteomics platform to identify specific diagnostic and predictive biomarkers for psoriasis, suggesting a great potential for application in translation studies and precision medicine in psoriasis and other immune-mediated diseases
ORGANISM(S): Homo Sapiens 
2019-03-13 | PXD013089 |
UnknownGenome-wide meta-analysis reveals shared new <i>loci</i> in systemic seropositive rheumatic diseases.

Objective

Immune-mediated inflammatory diseases (IMIDs) are heterogeneous and complex conditions with overlapping clinical symptoms and elevated familial aggregation, which suggests the existence of a shared genetic component. In order to identify this genetic background in a systematic fash...
S-EPMC6800208 | biostudies-literature
UnknownGuidelines for the use of flow cytometry and cell sorting in immunological studies.
Not available
S-EPMC9165548 | biostudies-literature
UnknownA cross-disease meta-GWAS identifies four new susceptibility loci shared between systemic sclerosis and Crohn's disease.
Genome-wide association studies (GWASs) have identified a number of genetic risk loci associated with systemic sclerosis (SSc) and Crohn's disease (CD), some of which confer susceptibility to both diseases. In order to identify new risk loci shared between these two immune-mediated disorders, we per...
S-EPMC7002703 | biostudies-literature
UnknownComplement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosis.
Copy number (CN) polymorphisms of complement C4 play distinct roles in many conditions, including immune-mediated diseases. We investigated the association of C4 CN with systemic sclerosis (SSc) risk. Imputed total C4, C4A, C4B, and HERV-K CN were analyzed in 26,633 individuals and validated in an i...
S-EPMC9534873 | biostudies-literature
UnknownGuidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).
These guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry community. They provide the theory and key practical aspects of flow cytometry enabling immunologists to avoid the common errors that often undermine immunological data. Notably, there are ...
S-EPMC7350392 | biostudies-literature
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