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TranscriptomicsExpression data from testis of day-7 Sohlh1 knock-out mice
Sohlh1 and Sohlh2 encode a germ cell-specific basic helix-loop-helix transcriptional regulator critical in spermatogonial differentiation. Seven-day-old Sohlh1 or Sohlh2 knockout and wild-type testes were arrayed on the Affy 430 2.0 platform. The following mice were analyzed at postnatal day 7: wild...
ORGANISM(S): Mus musculus 
2010-05-07 | E-GEOD-21525 | biostudies-arrayexpress
TranscriptomicsLim Homeobox Gene, LHX8, Is Essential for Mouse Oocyte Differentiation and Survival
Lhx8 is a member of the LIM-homeobox transcription factor family and preferentially expressed in oocytes and germ cells within the mouse ovary. We discovered that Lhx8 knockout females lose oocytes within 7 days after birth. At the time of birth, histological examination shows that Lhx8 deficient (L...
ORGANISM(S): Mus musculus 
2008-06-25 | E-GEOD-11897 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse ovaries lacking nobox from newborns
Nobox is a homeobox gene expressed in oocytes and critical in oogenesis. Nobox deficiency leads to rapid loss of postnatal oocytes. Early oocyte differentiation is poorly understood. We hypothesized that lack of Nobox perturbs global expression of genes preferentially expressed in oocytes as well as...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7775 | biostudies-arrayexpress
TranscriptomicsRegulation of early folliculogenesis by Sohlh1 and Sohlh2 in mouse ovary
This SuperSeries is composed of the following subset Series: GSE24815: Transcriptional changes in Sohlh1/Sohlh2 double knockout mouse newborn ovaries GSE24816: Transcriptional changes in Sohlh1 knockout and Sohlh2 knockout mouse newborn ovaries Refer to individual Series
ORGANISM(S): Mus musculus 
2010-10-22 | E-GEOD-24817 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse ovaries from Lhx8 Null newborns
Lhx8 is a homeobox gene expressed in oocytes and critical in oogenesis. Lhx8 deficiency leads to rapid loss of postnatal oocytes. Early oocyte differentiation is poorly understood. We hypothesized that lack of Lhx8 perturbs global expression of genes preferentially expressed in oocytes. We compared...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7774 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse ovaries from newborns
Microarray analysis of normal newborn ovarian transcript levels, for use in comparison to array based studies of differential expression in mouse knockout models. Experiment Overall Design: Newborn ovaries were pooled separately from wild type animals and total RNA isolated using RNeasy mini kit (Q...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7776 | biostudies-arrayexpress
TranscriptomicsCGH + SNP microarray analysis in consanguineous family with ovarian dysgenesis
homozygosity mapping in a family with ovarian failure Two affected and four unafected siblings from consanguineous family were studied to identify shared regions of homozygosity in affected females with gonadal dysgenesis
ORGANISM(S): Homo sapiens 
2014-10-16 | E-GEOD-62347 | biostudies-arrayexpress
TranscriptomicsTranscriptional changes in Sohlh1 knockout and Sohlh2 knockout mouse newborn ovaries
Sohlh1 and Sohlh2 are germ cell-specific basic helix-loop-helix transcription factors critical in early folliculogenesis. We discovered that Sohlh1 and Sohlh2 knockout females lose oocytes after birth and few remains by postnatal day 14. Here, we show that many genes preferentially expressed in the ...
ORGANISM(S): Mus musculus 
2010-10-22 | E-GEOD-24816 | biostudies-arrayexpress
TranscriptomicsTranscriptional changes in Sohlh1/Sohlh2 double knockout newborn mouse ovaries
Sohlh1 and Sohlh2 are germ cell-specific basic helix-loop-helix transcription factors critical in early folliculogenesis. Differential genes expression by both Sohlh1 and Sohlh2 deficiency in mouse newborn ovaries was accessed using microarray. RNA samples from Sohlh1/ Sohlh2 double knockout and wil...
ORGANISM(S): Mus musculus 
2010-10-22 | E-GEOD-24815 | biostudies-arrayexpress
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