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Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of the beta-carbolines family with anti-depressant properties, i...
2023-05-26 | MTBLS7533 | MetaboLights
Most eukaryotic proteins function as subunits within multimeric complexes. Imbalances in subunit levels disrupt assembly, leaving orphan proteins that are degraded by unclear quality control mechanisms. We identify the ubiquitin ligase HERC2 as a key regulator of this process. Proteomic analysis rev...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD071427 | Pride
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