Sort   by:  
 Page size 
ProteomicsA proteomic approach for systematic mapping of human deubiquitinating enzymes substrates
In the present study we implemented the bioUb approach to identify DUB substrates in a systemic manner. DUBs have been individually silenced so that the ubiquitination levels of their respective substrates are increased, and hence, upon isolation, susbtrates have been detected by mass spectrometry. ...
ORGANISM(S): Homo sapiens (Human) 
2021-04-29 | PXD025443 | Pride
Deubiquitinating enzyme Bioub Substrate Dubase Database 
ProteomicsThe ubiquitin ligase Ariadne-1 regulates NSF for neurotransmitter release
The aim of the present project was to identify putative substrates of Ariadne-1 (Ari-1), an essential E3 ubiquitin-ligase, in Drosophila heads. For that purpose we combined an in vivo ubiquitin biotinylation strategy termed bioUb with label free mass spectrometry analysis. In brief, BioUb strategy r...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-02-09 | PXD022701 | Pride
Synapse E3 ubiquitin ligase Neurotransmitter release Ubiquitination Ariadne-1 Drosophila Nsf 
ProteomicsIdentification of the circadian ubiquitylated proteome of Drosophila melanogaster.
Circadian clocks have evolved as time-measuring molecular devices to help organisms adapt their physiology to daily changes in light and temperature. Cycling transcription has been long hypothesized to account for the wealth of rhythmic protein abundance. However, cyclic degradation signals such as ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2018-05-22 | PXD005015 | Pride
Ubiquitylation Proteomics Posttranslational regulation Circadian rhythm 
ProteomicsFbxo42 promotes the degradation of Ataxin-2 granules to trigger terminal Xbp1 signaling
In Drosophila melanogaster, Fbxo42 acts downstream of Unfolded Protein Response activation but upstream of the apoptotic machinery. Fbxo42 associates through its N-terminal F-box domain with SkpA, a component of the RBX-SCF E3 ubiquitin ligase complex. Hence, in order to uncover Fbxo42 substrates, w...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-07-01 | PXD065621 | Pride
Alaxin-2 Upr Fbxo42 Xbp1 
UnknownA Proteomic Approach for Systematic Mapping of Substrates of Human Deubiquitinating Enzymes.
Not available
S-EPMC8124392 | biostudies-literature
UnknownBioE3 identifies specific substrates of ubiquitin E3 ligases.
Not available
S-EPMC10667490 | biostudies-literature
UnknownNeddylation inhibition prevents acetaminophen-induced liver damage by enhancing the anabolic cardiolipin pathway.
Not available
S-EPMC11293357 | biostudies-literature
UnknownMulti-Omics Integration Highlights the Role of Ubiquitination in CCl4-Induced Liver Fibrosis.
Not available
S-EPMC7729774 | biostudies-literature
UnknownQuantitative proteomic analysis of Parkin substrates in Drosophila neurons.
Not available
S-EPMC5387213 | biostudies-literature
ProteomicsNeddylation inhibition halts acetaminophen induced liver injury boosting anabolic cardiolipin pathway
Drug Induced-liver injury (DILI) is a significant cause of acute liver failure (ALF) and liver transplantation in the Western world. APAP overdose is a main contributor of DILI, leading to hepatocyte cell death through necrosis. Herein, we identified that neddylation, an essential post-translational...
ORGANISM(S): Mus Musculus 
PXD053221 |
Sort   by:  
 Page size