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TranscriptomicsMolecular Characterization of In Vivo Adjuvant Activity in Ferrets Vaccinated against Influenza Virus
The 2009 H1N1 influenza pandemic has prompted a significant need for the development of efficient, single-dose, adjuvanted vaccines. Here we investigated the adjuvant potential of CpG oligodeoxynucleotide (ODN) when used with a human seasonal influenza virus vaccine in ferrets. We found that the CpG...
ORGANISM(S): Mustela putorius furo 
2011-02-11 | E-GEOD-27248 | biostudies-arrayexpress
TranscriptomicsEarly CCL2 and CXCL10 chemokine expression correlates with lung pathology in Pandemic H1N1 Influenza A infection
Background: Pandemic H1N1 influenza A is a newly emerging strain of human influenza that is easily transmitted between people and has spread globally to over 116 countries. Human infection leads to symptoms ranging from mild to severe with lower respiratory complications observed in a small but sign...
ORGANISM(S): Mustela putorius furo 
2010-04-12 | E-GEOD-17079 | biostudies-arrayexpress
TranscriptomicsLungs of ferrets infected with either an H3N2 or H5N1 subtype of influenza A virus.
A global genomics approach was used to identify patterns of immune dysregulation during H5N1 influenza virus infection as the host response, in particular hyperchemokinemia, is thought to contribute to the extreme pathology associated with this disease. Keywords: time course Ferrets were inoculated ...
ORGANISM(S): Mustela putorius furo 
2010-05-15 | E-GEOD-9606 | biostudies-arrayexpress
TranscriptomicsEarly gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon-alpha2b stimulation
Background: Type I interferons (IFNs) are essential to the clearance of viral diseases, in part by initiating upregulation of IFN regulated genes (IRGs). A clear distinction between genes upregulated directly by virus and genes upregulated by secondary IFN production has not been made. Here we inve...
ORGANISM(S): Mustela putorius furo 
2010-12-01 | E-GEOD-22581 | biostudies-arrayexpress
TranscriptomicsGene expression profiles in lymph nodes from ferrets infected with A/California/07/2009
Pandemic H1N1 influenza A Human infection leads to symptoms ranging from mild to severe with lower respiratory complications observed in a small but significant number of infected individuals. Microarray analysis of the lymph nodes from ferrets infected with A/California/07/2009 shows intense gene u...
ORGANISM(S): Mustela putorius furo 
2013-01-28 | E-GEOD-36019 | biostudies-arrayexpress
TranscriptomicsAbsence of host innate immune responses in SARS-CoV-infected ferrets upon subsequent challenge
To further investigate the underlying mechanisms of severe acute respiratory syndrome (SARS) pathogenesis and evaluate the therapeutic efficacy of potential drugs and vaccines it is necessary to use an animal model that is highly representative of the human condition in terms of respiratory anatomy,...
ORGANISM(S): Mustela putorius furo 
2013-05-28 | E-GEOD-11704 | biostudies-arrayexpress
TranscriptomicsHosts responses in critical disease caused by pandemic H1N1
Critical disease caused by the new 2009 pandemic influenza virus (nvH1N1) is a challenge for physicians and scientist. As evidenced in SARS and H5N1, the development of an effective immune response plays a key role to overcome viral diseases. We studied host`s gene expression signatures, cytokine a...
ORGANISM(S): Homo sapiens 
2011-05-05 | E-GEOD-21802 | biostudies-arrayexpress
TranscriptomicsRole of Interleukin-6 in Influenza Pandemic A (H1N1pdm) Infection in Mice
Profile of host response in C57BL6/J mice infected with A/Mexico/4108/2009 (H1N1), spanning days 1 through 6 post-infection. Focused analysis on the involvement of IL-6 in the host response. Total RNA obtained from lung tissue collected from infected C57BL6/J mice at t = 1, 2, 3, 4, 5, 6 days post-...
ORGANISM(S): Mus musculus 
2012-06-24 | E-GEOD-31022 | biostudies-arrayexpress
TranscriptomicsAdjuvant induced attenuation of excessive inflammation in mice infected with pandemic H1N1 (H1N1pdm) virus
The reassorted human 2009 pandemic H1N1 (H1N1pdm) virus infected millions of people and caused thousands of deaths with associated immunopathology. Traditional immunosuppressants have limited capabilities in controlling inflammatory responses associated with severe influenza infections. A new ther...
ORGANISM(S): Mus musculus 
2014-09-10 | E-GEOD-41088 | biostudies-arrayexpress
TranscriptomicsMicroarray Expression Analysis of SIV infection of Sooty Mangabeys
Natural SIV infection of sooty mangabeys (SMs) does not progress to disease despite chronic virus replication. In contrast to pathogenic SIV infection of rhesus macaques (RMs), chronic SIV infection of SMs is characterized by low immune activation. To elucidate the mechanisms underlying this phenoty...
ORGANISM(S): Cercocebus torquatus atys 
2010-03-08 | E-GEOD-16147 | biostudies-arrayexpress
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