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Variation in individuals' adaptive immune response is believed to influence susceptibility to complex diseases in humans. The genetic basis of such variation is poorly understood. We measured gene expression from resting and activated CD4+ T cells derived from the peripheral blood of 348 healthy ind...
ORGANISM(S): Homo sapiens 
Metabolomics of pancreatic cancer cell are modified by metabolic enzyme MTHFD2. SW1990 cells were transfected with MTHFD2 siRNA and control siRNA. Cells were collected for metabolomics analysis.
ORGANISM(S): Homo Sapiens 
2021-02-18 | PXD024228 |
Inflammasomes are multicomplex proteins which drive pro-inflammatory cytokine responses and pyroptosis in innate immunity. Of which, the NLRP3 inflammasome is the most extensively studied, especially in myeloid immune cells such as macrophages. Conversely, the regulation of NLRP3 in non-immune cell ...
ORGANISM(S): Homo sapiens 
This study focuses on the molecular mechanisms underlying the response of duckweed (Landoltia punctata) to high nitrogen and phosphorus stress in biogas slurry from pig farms. Through integrated transcriptomic and proteomic analyses, this study systematically elucidates, for the first time, how duck...
ORGANISM(S): Landoltia Punctata 
Three groups of cells, including the control group, the senescent cells group, and the DMC-treated senescent cells group
ORGANISM(S): Homo Sapiens 
2023-11-23 | PXD047192 |
This study aims to investigate the role of Streptococcus mutans–derived extracellular vesicles (SmEVs) in the progression of oral squamous cell carcinoma (OSCC). We integrated transcriptomics and DIA-based quantitative proteomics to systematically analyze changes in gene expression in CAL-27 cells a...
ORGANISM(S): Streptococcus Mutans 
2025-12-23 | PXD072344 |
Macrophages play a pivotal role in the immune system through recognition and elimination of microbial pathogens. Toll-like receptors (TLRs) on macrophages interact with microbial substances and initiate signal transduction through intracellular adapters. TLR4, which is important for the response to ...
ORGANISM(S): Mus musculus 
Pattern recognition receptors (PRRs)-mediated innate immune responses are critical for host defense against microbial pathogens including RNA/DNA viruses. A growing number of coding genes and genes originally defined as non-coding RNAs (ncRNAs) are found to encode short peptides or proteins, named m...
ORGANISM(S): Homo Sapiens 
2023-01-12 | PXD039375 |
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