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ProteomicsMolecular basis of RanGTP-activated release of Histones H2A-H2B from Importin-9
Imp9 is the primary importin for shuttling H2A-H2B from the cytoplasm to the nucleus. It employs an unusual mechanism where the binding of RanGTP is insufficient to release H2A-H2B. The resulting stable RanGTP•Imp9•H2A-H2B complex gains nucleosome assembly activity with H2A-H2B able to be deposited ...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) Xenopus laevis (African clawed frog) 
2023-06-02 | PXD037571 | Pride
H2a-h2b Cryo-em Kap114 Importin-9 Rangtp Hdx-ms 
UnknownMechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex.
Not available
S-EPMC10629556 | biostudies-literature
GenomicsXPO5 is required for miRNA biogenesis and promotes primary miRNA processing independent of RanGTP
XPO5 is required for miRNA biogenesis and promotes primary miRNA processing independent of RanGTP
PRJNA438688 | ENA
ModelsGörlich2003_RanGTP_gradient
This model represents a concentration gradient of RanGTP across the nuclear envelope. This gradient is generated by distribution of regulators of RanGTPase. We have taken a log linear plot of graphs generated by GENESIS and compared with the experimental graphs. This model originates f...
2024-09-02 | BIOMD0000000192 | BioModels
UnknownRanGTP aids anaphase entry through Ubr5-mediated protein turnover.
Not available
S-EPMC4602037 | biostudies-literature
OtherXPO5 is required for miRNA biogenesis and promotes primary miRNA processing independent of RanGTP
XPO5 mediates nuclear export of miRNA hairpin precursors in a RanGTP-dependent manner. However, the requirement of XPO5 for global miRNA biogenesis and mammalian development and XPO5-associated RNA species are not determined. Here we show that XPO5 is required for mouse embryonic development and mor...
ORGANISM(S): Mus musculus Homo sapiens 
2020-02-19 | GSE111964 | GEO
UnknownA novel class of RanGTP binding proteins.
Not available
S-EPMC2139951 | biostudies-literature
UnknownMotorless transport of microtubules along tubulin, RanGTP, and salt gradients.
Not available
S-EPMC11530526 | biostudies-literature
UnknownMolecular basis of RanGTP-activated nucleosome assembly with Histones H2A-H2B bound to Importin-9.
Not available
S-EPMC9901172 | biostudies-literature
UnknownThe strategy for coupling the RanGTP gradient to nuclear protein export.
Not available
S-EPMC149899 | biostudies-literature
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