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ProteomicsSILAC-Tp (12 importins) - Extensive cargo identification reveals distinct biological roles of the 12 importin pathways
Importin-beta family proteins are nucleocytoplasmic transport receptors (NTRs), and they transport most nuclear proteins as their cargoes into and out of the nuclei. Human cells have 20 species of importin-beta family NTRs, of which 10 (importin-beta, transportin-1, -2, -SR, importin-4, -5, -7, -8, ...
ORGANISM(S): Homo sapiens (Human) 
2017-01-20 | PXD004655 | Pride
Nuclear transport Cargo Silac Transportin Importin Human Lc-ms/ms 
UnknownImportin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone.
Not available
S-EPMC6453568 | biostudies-literature
UnknownActive maintenance of nuclear actin by importin 9 supports transcription.
Not available
S-EPMC3295300 | biostudies-literature
UnknownImportin-9 regulates chromosome segregation and packaging in Drosophila germ cells.
Not available
S-EPMC8077489 | biostudies-literature
UnknownMolecular basis of RanGTP-activated nucleosome assembly with Histones H2A-H2B bound to Importin-9.
Not available
S-EPMC9901172 | biostudies-literature
ProteomicsMolecular basis of RanGTP-activated release of Histones H2A-H2B from Importin-9
Imp9 is the primary importin for shuttling H2A-H2B from the cytoplasm to the nucleus. It employs an unusual mechanism where the binding of RanGTP is insufficient to release H2A-H2B. The resulting stable RanGTP•Imp9•H2A-H2B complex gains nucleosome assembly activity with H2A-H2B able to be deposited ...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) Xenopus laevis (African clawed frog) 
2023-06-02 | PXD037571 | Pride
H2a-h2b Cryo-em Kap114 Importin-9 Rangtp Hdx-ms 
UnknownA revised model of nuclear actin import: Importin 9 competes with cofilin, profilin, and RanGTP for actin binding.
Not available
S-EPMC12860355 | biostudies-literature
UnknownA revised model of nuclear actin import: Importin 9 competes with cofilin, profilin, and RanGTP for actin binding.
Not available
S-EPMC12485787 | biostudies-literature
ProteomicsSILAC-Tp (12 importins)
Importin-beta family proteins are nucleocytoplasmic transport receptors (NTRs), and they transport most nuclear proteins as their cargoes into and out of the nuclei. Human cells have 20 species of importin-beta family NTRs, of which 10 (importin-beta, transportin-1, -2, -SR, importin-4, -5, -7, -8, ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-30 | MSV000080815 | MassIVE
UnknownMolecular basis of RanGTP-activated release of Histones H2A-H2B from Importin-9.
Not available
S-EPMC10527638 | biostudies-literature
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