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ProteomicsMolecular basis of RanGTP-activated release of Histones H2A-H2B from Importin-9
Imp9 is the primary importin for shuttling H2A-H2B from the cytoplasm to the nucleus. It employs an unusual mechanism where the binding of RanGTP is insufficient to release H2A-H2B. The resulting stable RanGTP•Imp9•H2A-H2B complex gains nucleosome assembly activity with H2A-H2B able to be deposited ...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) Xenopus laevis (African clawed frog) 
2023-06-02 | PXD037571 | Pride
H2a-h2b Cryo-em Kap114 Importin-9 Rangtp Hdx-ms 
ProteomicsAn Intrinsically Disordered Region of Ubp10 Governs its Specificity for Deubiquitinating H2A/H2B Dimers over Nucleosomes
Histone modifications perform a vast array of functions in regulating gene expression, DNA replication, and repair. Monoubiquitination of histone H2B at K123 in yeast (K120 in humans) is an intriguing modification because it is deposited cotranscriptionally, mediates the installation of several othe...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-07-16 | PXD051971 | Pride
Deubiqutinase Crosslinking mass spectrometry Ubiquitinated histone Ubp10 Single molecule fret Fact 
TranscriptomicsDynamics of yeast histone H2A and H2B phosphorylation in response to a double-strand break
In Saccharomyces cerevisiae, a single double-strand break (DSB) triggers extensive phosphorylation of histone H2A (known as gammaH2AX) over 50 kb on either side of the DSB. This modification is carried out by either of yeastM-^Rs checkpoint kinases, the ATM homolog, Tel1, or the ATR homolog, Mec1. ...
ORGANISM(S): Saccharomyces cerevisiae 
2013-12-15 | E-MTAB-1409 | biostudies-arrayexpress
UnknownMechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex.
Not available
S-EPMC10629556 | biostudies-literature
TranscriptomicsA Basic Domain in the Histone H2B N-terminal Tail is Important for Nucleosome Assembly by FACT
Nucleosome assembly in vivo requires assembly factors, such as histone chaperones, to bind to histones and mediate their deposition onto DNA. In yeast, the essential histone chaperone FACT (FAcilitates Chromatin Transcription) functions in nucleosome assembly and H2A-H2B deposition during transcript...
ORGANISM(S): Saccharomyces cerevisiae 
2016-08-10 | E-GEOD-80831 | biostudies-arrayexpress
GenomicsRecycling of H2A-H2B provides short-term memory of chromatin states [ChIP-Seq]
Recycling of H2A-H2B provides short-term memory of chromatin states [ChIP-Seq]
PRJNA842931 | ENA
GenomicsRecycling of H2A-H2B provides short-term memory of chromatin states [ChOR-Seq]
Recycling of H2A-H2B provides short-term memory of chromatin states [ChOR-Seq]
PRJNA843045 | ENA
UnknownSolution structure of the isolated histone H2A-H2B heterodimer.
Not available
S-EPMC4867618 | biostudies-literature
GenomicsRecycling of H2A-H2B provides short-term memory of chromatin states [SCAR-Seq]
Recycling of H2A-H2B provides short-term memory of chromatin states [SCAR-Seq]
PRJNA843044 | ENA
UnknownStructure of a single-chain H2A/H2B dimer.
Not available
S-EPMC7193513 | biostudies-literature
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