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TranscriptomicsAmplification of RANK- and c-Met-mediated signaling promotes metastatic colonization
We found that RANKL, expressed by cancer cells or derived from exogenous sources, consistently induced human prostate, breast, kidney, lung and liver cancer cells to colonize or metastasize to bone in an animal model of cancer bone metastasis. RANK-mediated signaling established a premetastatic nich...
ORGANISM(S): Homo sapiens 
2014-02-06 | E-GEOD-48432 | biostudies-arrayexpress
ProteomicsRank signaling drives basal cell-lineage infidelity leading to mammary tumorigenesis
Rank signaling regulates mammary gland development and epithelial cell differentiation. Rank receptor is expressed by mammary basal and luminal populations, but unlike that of luminal, the contribution of basal Rank signaling to mammary gland homeostasis remains poorly studied. Combining timely-regu...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-02 | PXD058134 | Pride
Rank signaling Phosphorylation Tumorogenesis 
TranscriptomicsGene expression analysis of transcriptome changes regulated by RANKL-RANK signaling in macrophage cell line RAW 264.7
Bone remodeling relies on the precise developmental control of osteoclasts that resorb bone and osteoblasts that lay down fresh bone matrix. The hematopoietically derived osteoclast follow a tigthly controlled genetic program where specific genes are up-regulated to aid bone resorption.Some of them ...
ORGANISM(S): Mus musculus 
2010-08-24 | E-GEOD-21639 | biostudies-arrayexpress
GenomicsDisruption of basal cell identity by Rank signaling drives mammary tumorigenesis
Disruption of basal cell identity by Rank signaling drives mammary tumorigenesis
PRJNA1139209 | ENA
GenomicsDisruption of basal cell identity by Rank signaling drives mammary tumorigenesis
Disruption of basal cell identity by Rank signaling drives mammary tumorigenesis
PRJNA1139725 | ENA
ProteomicsDisruption of basal cell identity by Rank signaling drives mammary tumorigenesis
Rank signaling regulates mammary gland development and epithelial cell differentiation. Rank receptor is expressed by mammary basal and luminal populations, but, unlike luminal Rank, the contribution of basal Rank signaling to MG homeostasis remains poorly studied. We have combined timely regulated ...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-02 | PXD054102 | Pride
Breast cancer Basal cell Identity infidelity Rank Mouse Mammary gland 
TranscriptomicsThe RANK/RANKL axis controls vascular dynamics in the bone marrow
Receptor activator of nuclear factor kappa B ligand (RANKL) is an essential cytokine that induces osteoclastic differentiation by monocyte-macrophage lineage precursors. Here, we showed that in addition to its conventional action, RANKL controls vascular permeability in the bone marrow, where it fac...
ORGANISM(S): Mus musculus 
2025-10-23 | E-MTAB-15929 | biostudies-arrayexpress
TranscriptomicsDisruption of basal cell identity by Rank signaling drives mammary tumorigenesis
Rank signaling regulates mammary gland development and epithelial cell differentiation. Rank receptor is expressed by mammary basal and luminal populations, but, unlike luminal Rank, the contribution of basal Rank signaling to MG homeostasis remains poorly studied. We have combined timely regulated ...
ORGANISM(S): Mus musculus 
2026-01-16 | GSE272902 | GEO
GenomicsDisruption of basal cell identity by Rank signaling drives mammary tumorigenesis
Rank signaling regulates mammary gland development and epithelial cell differentiation. Rank receptor is expressed by mammary basal and luminal populations, but, unlike luminal Rank, the contribution of basal Rank signaling to MG homeostasis remains poorly studied. We have combined timely regulated ...
ORGANISM(S): Mus musculus 
2026-01-16 | GSE272968 | GEO
GenomicsInhibition of RANK signaling interferes with macrophages' immunosuppressive role enhancing tumor immunity in breast adenocarcinomas
Inhibition of RANK signaling interferes with macrophages' immunosuppressive role enhancing tumor immunity in breast adenocarcinomas
PRJNA1231521 | ENA
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