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UnknownRisks of stroke and myocardial infarction after retinal artery occlusion and their time dependence: a systematic review and meta-analysis.

Background

Retinal artery occlusion (RAO) is an ophthalmic emergency that may signal underlying cardiovascular disease. Both stroke and myocardial infarction (MI) share pathophysiological mechanisms and risk factors with RAO. This systematic review aimed to assess the risks of stroke and MI ...
S-EPMC12537614 | biostudies-literature
UnknownActivated amino acid response pathway generates apatinib resistance by reprograming glutamine metabolism in non-small-cell lung cancer.
The efficacy of apatinib has been confirmed in the treatment of solid tumors, including non-small-cell lung cancer (NSCLC). However, the direct functional mechanisms of tumor lethality mediated by apatinib and the precise mechanisms of drug resistance are largely unknown. In this study, we demonstra...
S-EPMC9304404 | biostudies-literature
UnknownPD-1+ mast cell enhanced by PD-1 blocking therapy associated with resistance to immunotherapy.

Background

Programmed cell death protein 1 (PD-1) antibody has been approved for a variety of tumors, but its effective rate is unsatisfactory. New evidence suggests that mast cells are an important component of the tumor microenvironment and are associated with resistance to immunotherapy, ...
S-EPMC9947072 | biostudies-literature
UnknownTargeting ADRB2 enhances sensitivity of non-small cell lung cancer to VEGFR2 tyrosine kinase inhibitors.
Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) tyrosine kinase inhibitors (TKIs) have achieved remarkable clinical progress in the treatment of non-small-cell lung cancer; however, resistance has limited their therapeutic efficacy. Therefore, understanding the mechanisms of VEGF-TKI and ICI ...
S-EPMC8786837 | biostudies-literature
UnknownThe epidemiology and clinical characteristics of co-infection of SARS-CoV-2 and influenza viruses in patients during COVID-19 outbreak.
In this study, we performed a single-centered study of 307 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients. It was found that co-infection of SARS-CoV-2 and influenza virus was common during COVID-19 outbreak. And patients coinfected with SARS-CoV-2 and influenza B vir...
S-EPMC7307028 | biostudies-literature
UnknownNLRP6 is required for cancer-derived exosome-modified macrophage M2 polarization and promotes metastasis in small cell lung cancer.
Metastasis remains the primary cause of small cell lung cancer (SCLC)-related deaths. Growing evidence links tumor metastasis with a pre-metastatic microenvironment characterized by an anti-inflammatory response, immunosuppression, and the presence of tumor-derived exosomes. To clarify the relations...
S-EPMC9587220 | biostudies-literature
UnknownA new duck genome reveals conserved and convergently evolved chromosome architectures of birds and mammals.

Background

Ducks have a typical avian karyotype that consists of macro- and microchromosomes, but a pair of much less differentiated ZW sex chromosomes compared to chickens. To elucidate the evolution of chromosome architectures between ducks and chickens, and between birds and mammals, we p...
S-EPMC7787181 | biostudies-literature
UnknownBRD4-IRF1 axis regulates chemoradiotherapy-induced PD-L1 expression and immune evasion in non-small cell lung cancer.

Background

Chemoradiotherapy-induced PD-L1 upregulation leads to therapeutic resistance and treatment failure. The PD-1/PD-L1 blocking antibodies sensitize cancers to chemoradiotherapy by blocking extracellular PD-1 and PD-L1 binding without affecting the oncogenic function of intracellular ...
S-EPMC8792480 | biostudies-literature
UnknownActivation of NLRP3 inflammasome in lung epithelial cells triggers radiation-induced lung injury.

Background

Radiation-induced lung injury (RILI) is the most common and serious complication of chest radiotherapy. However, reported radioprotective agents usually lead to radiation resistance in tumor cells. The key to solving this problem is to distinguish between the response of tumor cel...
S-EPMC9872296 | biostudies-literature
UnknownA synbiotic intervention modulates meta-omics signatures of gut redox potential and acidity in elective caesarean born infants.

Background

The compromised gut microbiome that results from C-section birth has been hypothesized as a risk factor for the development of non-communicable diseases (NCD). In a double-blind randomized controlled study, 153 infants born by elective C-section received an infant formula suppleme...
S-EPMC8229302 | biostudies-literature
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