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p53 is critically important in preventing oncogenesis but its role in non-cancer biology remains unclear. Macrophages exist as two subtypes (M1 and M2). Nutlin-3a (p53 activator) inhibits M2 gene expression and phenotype. p53 acts by suppressing transcription of c-Myc and thence regulates expressio...
ORGANISM(S): Mus musculus 
Mitochondrial Ca2+ transport is a critical process in cellular physiology. One pathway for export occurs via Na+/Ca2+exchange (mito-NCX) machinery. TMEM65 has recently been shown to be crucial for mito-NCX activity, but its precise mechanistic role remains unknown. To evaluate whether TMEM65 forms a...
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD064897 | Pride
The LC-MS/MS-based in-depth proteomic analysis of the secretory proteins was performed using the CdM collected from the equal number of hCVPCs, hCMs and their 1:1 mixture. Then the label-free quantification of MS data and statistical analyses were used to compare the three groups.
ORGANISM(S): Homo Sapiens 
2025-02-24 | PXD061158 |
The goal of an effective AIDS vaccine is to generate immunity that will prevent HIV-1 acquisition. Despite limited progress towards this goal, renewed optimism has followed the recent success of the RV144 vaccine trial in Thailand. However, the lack of complete protection in this trial suggests th...
ORGANISM(S): Macaca mulatta 
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