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TranscriptomicsDeletion of DXZ4 on the human inactive X chromosome eliminates superdomains and impairs gene silencing
During interphase, the inactive X chromosome (Xi) adopts an unusual 3D configuration known as the Barr body and is largely transcriptionally silent. Despite the importance of X inactivation, little is known about the 3D configuration of Xi and its relationship to gene silencing. We recently showed t...
ORGANISM(S): Homo sapiens 
2016-07-19 | E-GEOD-71831 | biostudies-arrayexpress
UnknownX-inactivation in female human embryonic stem cells is in a nonrandom pattern and prone to epigenetic alterations.
Not available
S-EPMC2290804 | biostudies-literature
UnknownLandscape of X chromosome inactivation across human tissues.
Not available
S-EPMC5685192 | biostudies-literature
UnknownHSV-1 UL56 protein recruits cellular NEDD4-family ubiquitin ligases to suppress CD1d expression and NKT cell function.
Not available
S-EPMC11998485 | biostudies-literature
TranscriptomicsSix in situ Hi-C libraries of control and mESC auxin-inducible degrons for Scc1 and Ring1b.
In this experiment, we've examined chromatin conformation differences of E14 mESC against cohesin and Ring1b degrons. We performed a modified in situ Hi-C protocol from (Rao et al., 2014) that can be found in detail at (Díaz et al., 2018). Samples were digested with MboI restriction enzyme. The aim ...
ORGANISM(S): Mus musculus 
2020-01-23 | E-MTAB-7816 | biostudies-arrayexpress
TranscriptomicsDistinct roles of Tet1 and Tet2 in mouse embryonic stem cells (CMS-Seq)
The TET proteins TET1, TET2 and TET3 constitute a new family of dioxygenases that utilize molecular oxygen and the cofactors Fe(II) and 2-oxoglutarate to convert 5-methylcytosine (5mC) to 5-hydroxy-methylcytosine (5hmC) and further oxidation products in DNA1-5. Here we show that Tet1 and Tet2 have d...
ORGANISM(S): Mus musculus 
2014-01-16 | E-GEOD-50200 | biostudies-arrayexpress
UnknownBase composition is the primary factor responsible for the variation of amino acid usage in zebra finch (Taeniopygia guttata).
Not available
S-EPMC6281210 | biostudies-literature
TranscriptomicsDistinct roles of Tet1 and Tet2 in mouse embryonic stem cells (RNA-Seq)
The TET proteins TET1, TET2 and TET3 constitute a new family of dioxygenases that utilize molecular oxygen and the cofactors Fe(II) and 2-oxoglutarate to convert 5-methylcytosine (5mC) to 5-hydroxy-methylcytosine (5hmC) and further oxidation products in DNA1-5. Here we show that Tet1 and Tet2 have d...
ORGANISM(S): Mus musculus 
2014-01-16 | E-GEOD-50198 | biostudies-arrayexpress
GenomicsDissecting the dynamic changes of 5-hydroxymethylcytosine in T cell development and differentiation [MeDIP-Seq]
The discovery of TET proteins, enzymes that oxidize 5-methylcytosine (5mC) in DNA, has revealed novel mechanisms for the regulation of DNA methylation. We have mapped 5-hydroxymethylcytosine (5hmC) at different stages of T cell development in the thymus and T cell differentiation in the periphery. ...
ORGANISM(S): Mus musculus 
2014-08-04 | E-GEOD-59122 | biostudies-arrayexpress
UnknownAnalysis of the vp2 gene sequence of a new mutated mink enteritis parvovirus strain in PR China.
Not available
S-EPMC2903559 | biostudies-literature
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