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ProteomicsXPO1 is a critical player for Bortezomib resistance in Multiple Myeloma: A quantitative proteomic approach
Among the blood cancers, 13% mortality is caused by Multiple myeloma (MM) type of haematological malignancy. In spite of therapeutic advances in chemotherapy treatment, still MM remains an incurable disease is mainly due to emergence of chemoresistance. At present time, FDA approved bortezomib is th...
ORGANISM(S): Homo sapiens (Human) 
2019-09-09 | PXD013859 | Pride
Label free analysis Chemoresistance Bortezomib Xpo1 Multiple myeloma Itraq 
ProteomicsMultipronged quantitative proteomics reveals serum proteome alterations in breast cancer intrinsic subtypes
Being molecularly heterogeneous, breast cancer tends to be a complicated oncological disease with high incidence rates throughout the world. The primary aim of this study was to identify the set of serum proteins with discriminatory capabilities towards the four major subtypes of breast cancer. We e...
ORGANISM(S): Homo sapiens (Human) 
2017-05-15 | PXD006441 | Pride
Dige Swath Serum biomarkers Proteomics Breast cancer Itraq 
ProteomicsProteomic Alterations in Multiple Myeloma: A Comprehensive Study Using Bone Marrow Interstitial Fluid and Serum Samples
Multiple myeloma (MM) is a plasma cell associated cancer and the second most common hematological malignancies. Although researchers have been working on MM, comprehensive quantitative proteomic analysis of Bone Marrow Interstitial Fluid (BMIF) and Blood Serum is not yet reported. Being a proximal b...
ORGANISM(S): Homo sapiens (Human) 
2021-01-26 | PXD008927 | Pride
Multiple myeloma Serum biomarkers Swath-ms Bone marrow interstitial fluid Itraq Multipronged quantitative proteomics 2d-dige 
MetabolomicsVolatilomic insight of head and neck cancer via the effects observed on saliva metabolites
Head and neck cancer (HNC) is a heterogeneous malignant disease with distinct global distribution. Metabolic adaptations of HNC are significantly gaining clinical interests nowadays. Here, we investigated effects of HNC on differential expression of volatile metabolites in human saliva. We applied h...
2019-06-03 | MTBLS760 | MetaboLights
MetabolomicsMetabolomic alterations in invasive ductal carcinoma of breast: A comprehensive metabolomic study using tissue and serum samples
Invasive ductal carcinoma (IDC) is the most common type of breast cancer and the leading cause of breast cancer related mortality. In the present study, metabolomic profiles of 72 tissue samples and 146 serum samples were analysed using targeted liquid chromatography multiple reaction monitoring mas...
2018-10-16 | MTBLS552 | MetaboLights
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